Alpha-Fetoprotein, Hepatocellular Carcinoma, Liver Transplantation, Protein Induced by Vitamin K Absence or Antagonist-II
Conditions
Brief summary
As key biomarkers in HCC, AFP and PIVKA-II reflects biological features of tumor and has been widely applied for clinical diagnosis. Previous studies reported preoperative AFP and PIVKA-II are related to HCC recipient long-term survival after liver transplantation. However, there is no prospective study supporting these conclusions. This study aims to prospective collect liver transplantation cases from multiple transplant centers and further evaluate the prognostic role of preoperative AFP and PIVKA-II in liver transplantation for HCC.
Interventions
None listed
Sponsors
Shulan (Hangzhou) Hospital
Zhejiang University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Diagnosis of HCC based on CT or MRI imaging or needle biopsy confirming a histologic diagnosis of HCC. 2. Patients undergoing deceased donor liver transplantation for the first time.
Exclusion criteria
(1) patients who received split LT or simultaneous transplantation, (2) patients who received re-transplantation, (3) patients with macroscopic portal vein tumor thrombosis or other macrovascular invasion, (4) patients with incomplete follow-up, (5) taking warfarin at the time of LT biomarker measurements
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Recurrence free survival rate | 2024.4.1-2028.4.1 |
| Overall survival rate | 2024.4.1-2028.4.1 |
| Tumor recurrence rate | 2024.4.1-2028.4.1 |
Outcome results
None listed