Hereditary Diseases, Pancreatic Ductal Adenocarcinoma, Pancreatitis, Chronic
Conditions
Keywords
pancreatic ductal adenocarcinoma, screening programme, high-risk population
Brief summary
Pancreatic cancer is one of the diseases with the worst prognosis, which is mainly due to the initial asymptomatic prognosis. Unfortunately, the incidence of this disease in the Czech Republic is still increasing. In a certain proportion of patients, it is possible to predict the disease, e.g. due to family burdens. Regular follow-up of such individuals is the subject of the SCREPAN study: "Pancreatic Cancer Screening in High-Risk Persons".
Detailed description
Pancreatic ductal adenocarcinoma (PDAC) is one of the cancers with the worst prognosis. Mortality in this disease is almost equal to the incidence. In the Czech Republic, the incidence of this cancer has an upward trend, in 2017, 21.2 new cases per 100,000 people were reported, which represents a more than double increase compared to the data from the 1970s. Pancreatic cancer is associated with an extremely poor prognosis for several reasons. It is usually diagnosed at an advanced stage, which is often due to the asymptomatic course of the disease or non-specific symptoms, the lack of sensitive and specific tumor markers, and difficult diagnosis by imaging methods in the early stages. Five-year survival, regardless of clinical stage, is between 7-9%. Resectable disease is diagnosed in only 10% of patients, in which the 5-year survival rate is 37 %, locally advanced unresectable disease is detected in about 30 % of patients with a 5-year survival of 12 %, and metastatic disease is found in about 60 % of patients, with a 5-year survival rate of only around 3 %. The poor prognosis of this disease is also due to the limited possibilities of screening and curative intervention for a short "lead time" in rapidly metastatic disease. Pancreatic cancer screening is not suitable for the non-selected population. On the contrary, it is important for individuals with a high risk of developing this disease. In these subjects, early diagnosis during screening demonstrated a higher number of curative resections and longer survival.
Interventions
PROCEDUREendoscopic ultrasonography
endoscopic ultrasonography - frequency defined by arm
PROCEDUREmagnetic resonance
magnetic resonance - frequency defined by arm
DIAGNOSTIC_TESTlaboratory examination
hematology, biochemistry, Na+, K+, Cl-, Ca2+, bilirubin, ALT, AST, GGT, ALP, lactate dehydrogenase, creatinine, urea, fasting glycemia, HbA1c, alpha-amylase, LPS, albumin, total protein, CA19-9, CEA
Sponsors
Masaryk Memorial Cancer Institute
Masaryk University
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SCREENING
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* willing to participate in the study * age 18+ * arms specific criteria: A: * chronic pancreatic disease in the context of cystic fibrosis or chronic pancreatitis * age 50+ B1: * confirmed Peutz-Jegherson syndrome (mutSTK11) + age over 35 years or 10 years earlier than pancreatic ductal adenocarcinoma was diagnosed in the youngest family member * familial melanoma syndrome (mutCDKN2A) + age over 40 years or 10 years before pancreatic ductal adenocarcinoma was diagnosed in the youngest family member * confirmed hereditary pancreatitis (mutPRSS1) + age over 40 years or 20 years after the first attack B2: * confirmed diagnosis of hereditary syndrome (Lynch syndrome /mutMLH1, mutMSH2, mutMSH6, mutPMS2, mutEPCAM/, HBOC /mutBRCA1, mutBRCA2, mutPALB2, mutATM/, familial adenomatous polyposis /mutAPC/, Li-Fraumeni syndrome /mutTP53/) * at least one relative with a diagnosis of pancreatic ductal adenocarcinoma in family anamnesis at the same time (Grade I or II relative) * age over 50 years, or 10 years before the pancreatic ductal adenocarcinoma was diagnosed in the youngest relative - which comes first C: * positive family anamnesis of pancreatic ductal adenocarcinoma without hereditary syndrome context * age 50+ or 10 years earlier than the youngest relative with pancreatic ductal adenocarcinoma - screening is recommended for all first-degree relatives of affected family members
Exclusion criteria
* Inability to undergo radical curative surgery for a pancreatic tumor. * Inability to undergo scheduled imaging examinations. * Incurable malignant cancer.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of participants with newly diagnosed pancreatic ductal adenocarcinoma | From date of subject enrollment annualy in determined examinations according to the protocol schedule until the date of PDAC diagnosis or up to 60 months of subject participation in the study | Number of participants (in risk population) with newly diagnosed pancreatic cancer |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Methods yield comparison | through study completion, an average of 1 year | Comparison of magnetic resonance versus endoscopic ultrasonography yield |
| Screening methods cost-effectiveness | through study completion, an average of 1 year | Comparison of magnetic resonance versus endoscopic ultrasonography cost effectiveness |
| KRAS mutation status evaluation | From the date of subject enrollment annualy in determined examinations according to the protocol schedule until the date of PDAC diagnosis or up to 60 months of subject participation in the study | KRAS mutation status defined by number of positive droplets on drop digital PCR using material from liquid biopsy |
Countries
Czechia
Contacts
CONTACTMartina Lojova, Ph.D.
CONTACTDita Kozakova, Ing.
Outcome results
None listed