Alzheimer Dementia (AD)
Conditions
Brief summary
The purpose of this study is to find out the difference in genetic test results between Alzheimer's dementia patients and healthy subjects. The investigators want to identify genes that are importantly related to Alzheimer's dementia.
Interventions
None listed
Sponsors
MinYoung Kim, MD, PhD
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
60 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
1. Inclusion Criteria: Alzheimer's dementia patient * Adult patients over 60 years old * Patients with a Alzheimer's dementia patient * Total Korean version of mini-mental state examination (K-MMSE) score less than 24 * Total Clinical Dementia Rating (CDR) over 0.5 2. Inclusion Criteria: healthy subjects * Adult healthy over 60 years old * Total Korean version of mini-mental state examination (K-MMSE) over 24 * Total Clinical Dementia Rating (CDR) is 0 3.
Exclusion criteria
* Those with severe medical conditions such as unstable conditions of the cardiovascular system, digestive system, respiratory system, endocrine system, etc., who are in poor general condition * In the case of a person with impaired consent (MMSE less than 10 points), if not accompanied by a guardian * Other cases where the researcher determines that participation in this clinical trial is not appropriate (Patients who are participating in other studies or have participated in other studies within the past 30 days can also participate in this study.)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| genetic analysis | Baseline | 5cc blood collection for genetic testing |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Measurement of Korean version of mini-mental state examination (K-MMSE) | screening, Baseline | K-MMSE is a measurement of cognitive level. Any score of 24 or more (out of 30) indicates a normal cognition. Below this, scores can indicate severe(≤9 points), moderate (10-18 points) or mild (19-23 points) cognitive impairment(MCI). The raw score may also need to be corrected for educational attainment and age. |
| Measurement of Clinical Dementia Rating (CDR) | screening, Baseline | CDR is a rating scale for staging patients diagnosed with dementia. The CDR evaluates cognitive, behavioral and functional aspects of Alzheimer disease and other dementias. It is calculated on the basis of testing six different cognitive and behavioral domains such as memory, orientation, judgment and problem solving, community affairs, home and hobbies performance, and personal care. The CDR is based on a scale of 0-3: no dementia (CDR = 0), questionable dementia (CDR = 0.5), MCI (CDR = 1), moderate cognitive impairment (CDR = 2) and severe cognitive impairment (CDR = 3) |
| Measurement of Geriatric Depression Scale (GDSd) | Baseline | GDS is a 30-item self-report assessment used to identify depression in the elderly. One point is assigned to each answer and the cumulative score is rated on a scoring grid. The grid sets a range of 0-9 as normal, 10-19 as mildly depressed, and 20-30 as severely depressed. |
Contacts
Primary ContactMinYoung Kim, MD, PhD
Outcome results
None listed