Cognitive Change
Conditions
Keywords
cognition
Brief summary
The goal of this accelerated longitudinal observational cohort study is to advance our understanding of cognitive variability in children aged 7 to 10 at first measurement. The CODEC study aims to integrate experience sampling methods, longitudinal designs, deep phenotyping cohorts, and state-of-the-art statistical methodologies to investigate three core questions: 1. How does cognitive variability differ between individuals? 2. What are the neural, psychological, and environmental mechanisms that underlie cognitive variability? 3. What are the long-term consequences and outcomes associated with differences in cognitive variability?
Interventions
None listed
Sponsors
Radboud University Medical Center
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
7 Years to 13 Years
Healthy volunteers
Yes
Inclusion criteria
* In order to be eligible to participate in the behavioural arm of this study, a subject must meet all of the following criteria: * Between the ages of 7 and 10 years at the moment of the first assessment. In order to be eligible to participate in the imaging arm of this study, a subject must meet all of the following criteria: * Between the ages of 8 and 10 years at the moment of the first assessment.
Exclusion criteria
* A potential subject will be excluded from participation in the study if the participant indicates not understanding the instructions of the behavioural tasks due to a language barrier. In the imaging arm of the study, a potential subject who meets any of the following criteria will further be excluded from participation in the imaging arm of the study: * History of neurological or psychiatric illness. * History of using psychotropic medications. * Contraindications for MRI. * Metal parts that cannot be removed, are present in or on upper body, e.g. plates, screws, aneurysm clips, metal splinters, piercings or medical plasters. (exception: dental fillings, crowns, a metal wire behind the teeth, tattoos and contraceptive coils). * Body containing metal fragments, in particular in the eye, e.g., caused by injuries when working with metal. * History of brain surgery. * Active implant(s) (e.g. pacemaker, neurostimulator, insulin pump, ossicle prosthesis) * Using a medical plaster that cannot or may not be taken off (e.g. nicotine plaster)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Total score for Highly Sensitive Child scale at follow-up | two years after baseline | Participant-reported 12-item Dutch version of the HSC scale measured at follow-up. Each item is scored on a scale from 1-strongly disagree to 7-strongly agree |
| Originality score for the Alternative Uses Tasks at follow-up | two years after baseline | Originality score of responses on an alternative uses task at follow-up. |
| Total score for Parent-reported Mind Excessively Wandering Scale scale at baseline | an average of 1 year | Parent reported 12-item Dutch version of the MEWS scale measured at baseline. Each item is scored on a scale from 0 (not at all or rarely) to 3 (nearly all of the time or constantly) |
| Total score for Parent-reported Socio-demographic questionnaire at baseline | an average of 1 year | Parent reported socio-demograpic questionnaire at baseline. Total score on SES related questions (highest level of educationm professional situation) will be measured. |
| Total score for Parent-reported Socio-demographic questionnaire at follow-up | two years after baseline | Parent reported socio-demograpic questionnaire at baseline. Total score on SES related questions (highest level of education, professional situation) will be measured. |
| Total score for Mind Excessively Wandering Scale scale at follow-up | two years after baseline | Participant reported 12-item Dutch version of the MEWS scale measured at follow-up. Each item is scored on a scale from 0 (not at all or rarely) to 3 (nearly all of the time or constantly) |
| Total score for Parent-reported Mind Excessively Wandering Scale scale at follow-up | two years after baseline | Parent reported 12-item Dutch version of the MEWS scale measured at follow-up. Each item is scored on a scale from 0 (not at all or rarely) to 3 (nearly all of the time or constantly) |
| pupil dilation during reasoning task at baseline | an average of 1 year | pupil dilation recording through eye-tracking at baseline measurement when participants perform fluid reasoning task. |
| Naturalistic viewing fMRI at baseline | an average of 1 year | Naturalistic viewing fMRI at baseline measurement. |
| Reaction times from the vocabulary cognitive task | Through study completion, an average of 3 years | RT from accurate responses from the vocabulary task in the cognitive battery during burst assessment (3x a day, 5x a week) and up to 2 additional occasions per year. |
| Reaction times from the exploration cognitive task | Through study completion, an average of 3 years | RT from accurate responses from the exploration task in the cognitive battery during burst assessment (3x a day, 5x a week) and up to 2 additional occasions per year. |
| Reaction times from the Working Memory cognitive task | Through study completion, an average of 3 years | RT from accurate responses from the WM task in the cognitive battery during burst assessment (3x a day, 5x a week) and up to 2 additional occasions per year. |
| Reaction times from the speed cognitive task | Through study completion, an average of 3 years | RT from accurate responses from the speed raction time task in the cognitive battery during burst assessment (3x a day, 5x a week) and up to 2 additional occasions per year. |
| Reaction times from the fluid reasoning cognitive task | Through study completion, an average of 3 years | RT from accurate responses from the fluid reasoning task in the cognitive battery during burst assessment (3x a day, 5x a week) and up to 2 additional occasions per year. |
| Mood score on smiley slider | Through study completion, an average of 3 years | The current mood of the participant on a smiley slider from 0-100 during burst assessment (3x a day, 5x a week) and up to 2 additional occasions per year. |
| Sleep score on smiley slider | Through study completion, an average of 3 years | The current level of tiredness of the participant on a smiley slider from 0-100 during burst assessment (3x a day, 5x a week) and up to 2 additional occasions per year. |
| MP-RAGE MRI sequence baseline | an average of 1 year | Structural MP-RAGE MRI scan at baseline measurement |
| Functional MRI sequence of low time constraint reasoning task at baseline | an average of 1 year | Functional MRI scan at baseline measurement when participants perform fluid reasoning task with low time contraint. |
| gaze direction during reasoning task at baseline | an average of 1 year | gaze direction recording through eye-tracking at baseline measurement when participants perform fluid reasoning task. |
| Naturalistic viewing fMRI at follow-up | two years after baseline | Naturalistic viewing fMRI at follow-up measurement. |
| Functional MRI sequence of high time constraint reasoning task at follow-up | two years after baseline | Functional MRI scan at follow-up measurement when participants perform fluid reasoning task with high time contraint. |
| gaze direction during reasoning task at baseline at follow-up | two years after baseline | gaze direction recording through eye-tracking at follow-up measurement when participants perform fluid reasoning task. |
| pupil dilation during reasoning task at baseline at follow-up | two years after baseline | pupil dilation recording through eye-tracking at follow-up measurement when participants perform fluid reasoning task. |
| Functional MRI sequence of low time constraint reasoning task at follow-up | two years after baseline | Functional MRI scan at follow-up measurement when participants perform fluid reasoning task with low time contraint. |
| Sparse MP2-Rage MRI sequence baseline | an average of 1 year | Structural Sparse MP2-Rage MRI scan at baseline measurement |
| Diffusion weighted imaging MRI sequence baseline | an average of 1 year | Diffusion weighted imaging MRI scan at baseline measurement |
| MP-RAGE MRI sequence follow up | two years after baseline | Structural MP-RAGE MRI scan at follow up measurement |
| Sparse MP2-Rage MRI sequence follow up | two years after baseline | Structural Sparse MP2-Rage MRI scan at follow up measurement |
| Diffusion weighted imaging MRI sequence follow up | two years after baseline | Diffusion weighted imaging MRI scan at follow up measurement |
| Total score for Highly Sensitive Child scale at baseline | an average of 1 year | Participant reported 12-item Dutch version of the HSC scale measured at baseline. Each item is scored on a scale from 1-strongly disagree to 7-strongly agree |
| Total score for Strengths and difficulties questionnaire at baseline | an average of 1 year | Parent reported 25-item Dutch version of the SDQ measured at baseline. Each item is scored (0-not at all/only a little, 1-quite a lot, 2-a great deal) |
| Total score for BRIEF-2 questionnaire at baseline | an average of 1 year | Parent reported Dutch version of the Behaviour Rating Inventory of Executive Function 2 measured at baseline. |
| Total score for BRIEF-2 questionnaire at follow-up | two years after baseline | Parent reported Dutch version of the Behaviour Rating Inventory of Executive Function 2 measured at follow-up. |
| Total score for Strengths and difficulties questionnaire at follow-up | two years after baseline | Parent reported 25-item Dutch version of the SDQ measured at follow-up. Each item is scored (0-not at all/only a little, 1-quite a lot, 2-a great deal) |
| Total score for Mind Excessively Wandering Scale scale at baseline | an average of 1 year | Participant reported 12-item Dutch version of the MEWS scale measured at baseline. Each item is scored on a scale from 0 (not at all or rarely) to 3 (nearly all of the time or constantly) |
| Originality score for the Alternative Uses Tasks at baseline | an average of 1 year | Originality score of responses on an alternative uses task at baseline. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Decibel of background noise during cognitive testing | Through study completion, an average of 3 years | DB recording of background noise when performing the cognitive tasks at the start of the testing |
| Academic school result baseline | an average of 1 year | cito-scores, academic results on national test obtained through schools at baseline |
| Academic school result follow-up | two years after baseline | cito-scores, academic results on national test obtained through schools at follow-up |
| Parent reaction times on cognitive battery at baseline | an average of 1 year | Parents performed RT on accurate responses in measures on the complete cognitive battery (vocabulary, reasoning, exploration, working memory and speed) at baseline |
| Parent reaction times on cognitive battery at follow-up | two years after baseline | Parents performed RT on accurate responses in measures on the complete cognitive battery (vocabulary, reasoning, exploration, working memory and speed) at follow-up |
| motivation rating for cognitive tasks | Through study completion, an average of 3 years | Rating from least to most fun cognitive task once a year after completing the cognitie battery 10 times in the burst week |
Countries
Netherlands
Contacts
Primary ContactRogier Kievit
Backup ContactIlse Coolen
Outcome results
None listed