Healing Surgical Wounds, Pain
Conditions
Keywords
photobiomodulation, L-PRF, pain, bone healing, soft tissue healing, third molar
Brief summary
The aim of this study is to compare leukocyte and platelet-rich fibrin (L-PRF) and photobiomodulation (PBM) applications, which have been repeatedly reported to be superior to control groups, in terms of pain, soft tissue and bone healing in tooth extraction sockets.
Detailed description
After sample size calculation, healthy volunteers were included in the study. Both teeth of these individuals with bilaterally impacted wisdom teeth were extracted simultaneously. Photobiomodulation (PBM) or leukocyte and platelet rich fibrin (L-PRF), an autogenous blood product, was randomly applied to the right or left side extraction sockets. Volunteers were called for repeat sessions (days 2,4,7,7,11,11,14,18 and 21) for the PBM treated side. Follow-ups were performed for pain (days 2,4,7) and soft and bone tissue healing.
Interventions
DEVICEphotobiomodulation
Photobiomodulation application at different extraoral and intraoral points for 60 seconds with a wavelength of 940 nm in repeated sessions after the extraction of third molar
Leukocyte and platelet rich fibrin ( blood product centrifuged for 12 minutes at 2700rpm) application after third molar extraction, single session.
Sponsors
Akdeniz University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Investigator, Outcomes Assessor)
Intervention model description
Since the groups were formed on the same individual, only which side would be the PBM and which side would be the L-PRF group was determined by coin-flip method (simple randomization).
Eligibility
Sex/Gender
ALL
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* American Society of Anesthesiologists (ASA) Class-I healthy volunteers * Between 18 and 40 years of age who had wisdom teeth (Pell and Gregory Class II, Position B) with bone retention in bilateral symmetrical position with an indication for extraction, and had second molars in the mouth, * Not use steroids or anti-inflammatory drugs in the last 3 months.
Exclusion criteria
* Patients with pericoronitis, * Smoking habits * Active periodontal disease * Pregnancy, * Breastfeeding * Unable to give personal consent, and those with missing physical examination and follow-up records were excluded.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Newly formed bone (Healing at extraction sockets) | Bone healing at the end of 1st and 3rd months after third molar extractions | Newly formed bone assessed on Panoramic x-ray with Image J programme |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Soft tissue healing | End of 1st, 2nd week and 1st month after tooth extraction | Landry Index scores (1: Very poor, 2: Poor, 3: Good, 4. Very Good, 5. Excellent healing) |
| Probing depth | End of 1st, 2nd week and 1st month after tooth extraction | Probing depth of second mandibular molar distal pocket (millimeters) |
Other
| Measure | Time frame | Description |
|---|---|---|
| Postoperative pain | Postoperative 2nd, 4th and 7th days | Visual Analogue Scale (0=no pain, 10=unbearable pain) |
Countries
Turkey (Türkiye)
Outcome results
None listed