Brain Edema, Diabetic Ketoacidosis, Metabolic Acidosis
Conditions
Keywords
Type 1 diabetes mellitus (Type 1 DM), Diabetic Ketoacidosis (DKA), Capnography, Blood gas, Integrated Pulmonary Index, End tidal Carbon Dioxide (EtCO2)
Brief summary
This is the first and only study conducted on the use of capnography in children diagnosed with DKA to evaluate the initial clinical grading of DKA, monitor clinical improvement, and predict complications such as brain edema.
Detailed description
Purpose: In this study, the contribution of this non-invasive follow-up method to the management of DKA and the reduction of the frequency of invasive procedures was investigated in patients diagnosed with diabetic ketoacidosis (DKA) in the pediatric emergency department and followed up with capnography Method: This study is a prospective clinical study. Between October 2020- November 2022, EtCO2 and IPI follow-up of 0-18 year-old pediatric patients diagnosed with DKA in the Pediatric Emergency Service of Akdeniz University Medical Faculty Hospital was performed by capnography. DKA diagnosis, grading, clinical follow-up and treatment termination criteria of the patients were determined according to the ISPAD 2018 Diagnosis and Treatment Guidelines. In the study; During the clinical follow-up, changes in GCS, blood glucose, vital, blood gas and capnograph parameters were examined. Demographic data were analyzed in all patients and in groups of patients who underwent DKA grading. GCS, blood gas and capnograph parameters were compared in the patient groups with DKA grading. Diagnostic test performances of blood gas and capnograph parameters were compared to detect low GCS
Interventions
DIAGNOSTIC_TESTCapnography
This is non-invasive follow-up method to the management of DKA and the reduction of the frequency of invasive procedures was investigated in patients diagnosed with diabetic ketoacidosis (DKA) in the pediatric emergency department and followed up with capnography.
Sponsors
Ceren Kahraman
Akdeniz University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
15 Days to 18 Years
Healthy volunteers
No
Inclusion criteria
* The study group consisted of pediatric patients aged 0-18 years who were diagnosed with Diabetic Ketoacidosis and applied to Akdeniz University pediatric emergency department. * Written consent was obtained.
Exclusion criteria
• Who did not give written consent were not included in the study.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Correlation between PCO2 and EtCO2 | 2 days | The positive linear correlation between PCO2 and EtCO2 indicates that acidosis can be monitored with EtCO2. |
| Correlation between Integrated Pulmonary Index and degree of acidosis | 2 days | Detection of a positive linear correlation between those with Integrated Pulmonary Index \<8 and the degree of acidosis |
| Prediction of cerebral edema with Integrated Pulmonary Index | 2 days | Detection of significant decrease in Glasgow Coma Scale (GCS\<13) in patients with Integrated Pulmonary Index \<4 |
Countries
Turkey (Türkiye)
Outcome results
None listed