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Social Network Overdose Prevention and Education Intervention

A Social Diffusion Fatal Overdose Prevention Intervention: Assessing the Effectiveness of People Who Use Opioids as Peer Educators in Training Using & Non-using Networks on Overdose & Stigma Reduction

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT06327061
Enrollment
600
Registered
2024-03-25
Start date
2024-06-01
Completion date
2029-04-01
Last updated
2026-03-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Drug Overdose

Brief summary

The purpose of this study is to test a social intervention focused on overdose prevention and care. In the investigators prior work, the investigators have shown that people who use opioids (PWUO) can be effective peer educators (PEs).

Detailed description

The purpose of this study is to test a social intervention focused on overdose prevention and care. In the investigators prior work, the investigators have shown that people who use opioids (PWUO) can be effective peer educators (PEs). The investigators have utilized PEs for overdose prevention in interventions that have focused on training network members who use drugs to respond to an overdose. Yet, many overdoses are witnessed by people who do not use drugs. Additionally, many PWUO report using drugs at home and living with someone who does not use drugs, which highlights the importance of training non-using network members on overdose response. Based on pilot data, the investigators propose expanding an overdose peer education intervention to focus on non-using network members. The intervention seeks to prepare network members to respond to an overdose and normalize discussions about overdose prevention planning between index PWUO and non-using network members. The intervention condition consists of 3 individual sessions focused on overdose prevention and response. This condition is designed to train index study participants to be Peer Educators. In addition to the three sessions, the non-drug using network member will be offered one session. The control condition is only 1 session focused on overdose prevention and response. Both intervention and control participants will invite social network members to take part in data collection activities

Interventions

BEHAVIORALNetwork overdose prevention

Participants are taught overdose prevention methods with network members.

BEHAVIORALStandard of care health education

Participants will receive the standard of care for overdose prevention.

Sponsors

Johns Hopkins Bloomberg School of Public Health
Lead SponsorOTHER
National Institute on Drug Abuse (NIDA)
CollaboratorNIH

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
SINGLE (Subject)

Masking description

Both groups receive overdose prevention training

Intervention model description

a standard two-group clinical trial, one group is the experimental, the other the control

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* self-reported illicit opioid use at least 2 times in the past two weeks; * age 18 and older; * living in the Baltimore metropolitan region; * willing to engage in peer education; and * having and willing to recruit at least one non-using network member.

Exclusion criteria

Participants without the cognitive ability to provide informed consent and have the physical ability to participate in in-person intervention sessions.

Design outcomes

Primary

MeasureTime frameDescription
Number of drug overdoses3-monthsNumber of drug overdoses in prior three months
Participant drug use3-monthsProportion of times participants tested positive for drugs of fentanyl and xylazine using test strips in the prior 3 months.

Secondary

MeasureTime frameDescription
Number of Network member contacts3-monthsNumber of network members talked to about overdose prevention in prior 3 months

Countries

United States

Contacts

CONTACTCarl Latkin, PhD
carl.latkin@jhu.edu(410)955-3972
PRINCIPAL_INVESTIGATORCarl Latkin, PhD

Johns Hopkins University

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 5, 2026