Papillary Thyroid Cancer
Conditions
Brief summary
To evaluate the clinical outcomes of image-guided thermal ablation versus thyroid lobectomy for the treatment of papillary thyroid microcarcinoma
Interventions
PROCEDUREthyroid lobectomy
thyroid lobectomy
PROCEDUREimage-guided thermal ablation
radiofrequency ablation or microwave ablation or laser ablation
Sponsors
Chinese PLA General Hospital
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. solitary papillary thyroid carcinoma confirmed by fine-needle aspiration or core-needle biopsy; 2. largest diameter ≤10 mm; 3. no evidence of extrathyroidal extension( no signs of unsmooth thyroid capsule or involvement of the perithyroidal tissue) on ultrasound; 4. no evidence of cervical lymph node metastasis on US or neck CT; 5. no distant metastasis on chest CT; 6. no history of neck irradiation.
Exclusion criteria
* (1)aggressive subtype of papillary thyroid microcarcinoma confirmed by biopsy(1); (2)multiple tumors; (3) incomplete data or lost follow-up
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| disease progression | more than 5 years | cervical lymph node metastases, recurrent tumors and persistent tumors |
| disease-free survival | more than 5 years | disease-free survival calculated from treatment initiation to disease progression or the last follow-up date |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| cost | 1 week | The ablation cost included preoperative examinations, treatment, local anesthesia and ablation needle costs. The lobectomy cost included preoperative examinations, treatment, general anesthesia, hospital bed, nursing and postoperative medication |
| complications | 1 week | complications after surgery or ablation |
| hospitalization | 1 week | hospitalization for surgery or ablation |
| estimated blood loss | 1 hour | estimated blood loss after surgery or ablation |
| procedure time | 1 hour after treatment | Ablation procedure time was defined from US evaluation for the design of insertion way to treatment terminated. Lobectomy procedure time was defined from incision to closure, not including the anesthesia time. |
Outcome results
None listed