Association Between Surgical Timing and Route of Total Hysterectomy After LEEP and Perioperative Risk in Patients With Cervical HSIL

Association Between Surgical Timing and Route of Total Hysterectomy After Loop Electrosurgical Excision Procedure and Perioperative Risk in Patients With Cervical High-grade Squamous Intraepithelial Lesion

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06325592

Enrollment

826

Registered

2024-03-22

Start date

2023-10-01

Completion date

2024-03-01

Last updated

2024-03-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

High-Grade Squamous Intraepithelial Lesions

Brief summary

This study aimed to analyze perioperative information in patients with high-grade squamous intraepithelial lesion (HSIL) undergoing total hysterectomy (TH), offering insights into optimal surgery timing, selecting the operation path, and enhancing surgical operation details.

Interventions

PROCEDUREsurgical timing and operation path

surgical timing; laparoscopic hysterectomy or abdominal hysterectomy

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Healthy volunteers

Inclusion criteria

* patients were confirmed with HSIL through pathology at our hospital or another tertiary facility, with additional confirmation via pathological consultation at our facility; * LH or abdominal hysterectomy (AH) +/- bilateral fallopian tube or bilateral adnexectomy was performed after LEEP; * the patient had no history of systemic malignancies.

Exclusion criteria

* severe medical and surgical complications; * an extensive or subextensive hysterectomy was performed; * surgical removal scope involving tissues (such as lymph nodes) or organs (such as the appendix) other than the uterus, ovaries, and fallopian tubes; * fever symptoms within the last month; * incidence of pelvic and abdominal infections, vaginitis, or similar conditions within the past month.

Design outcomes

Primary

Measure	Time frame	Description
Postoperative fever	Within 7 days of surgery	Use a thermometer to measure your temperature
Postoperative therapeutic use of antibiotics	Within 7 days of surgery	Postoperative therapeutic use of antibiotics

Secondary

Measure	Time frame	Description
Postoperative erythrocyte count	Within 7 days of surgery	Postoperative erythrocyte count
Postoperative albumin number	Within 7 days of surgery	Postoperative albumin number
Postoperative hemoglobin	Within 7 days of surgery	Postoperative hemoglobin
Postoperative complications	Within 7 days of surgery	Postoperative complications
Postoperative hospitalization days	Date of surgery to date of discharge	Postoperative hospitalization days
Postoperative CRP value	Within 7 days of surgery	Postoperative CRP value
Postoperative white blood cell count	Within 7 days of surgery	Postoperative white blood cell count

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026