Brain Mechanisms of Reducing Polysubstance Use

Brain Mechanisms of Reducing Polysubstance Use Following a Novel Body-mind Intervention 2

Status

Recruiting

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT06324786

Enrollment

Registered

2024-03-22

Start date

2023-09-01

Completion date

2026-08-31

Last updated

2025-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Multiple Drug Use

Brief summary

The proposed study will test whether neurofeedback (NF) could optimize integrative body-mind training (IBMT) practice.

Detailed description

The proposed study will test whether real-time NF could optimize IBMT practice and improve effects in reducing polysubstance use through targeting self-control networks in the brain.

Interventions

BEHAVIORALIBMT

IBMT is an effortless mindfulness technique

BEHAVIORALNF

NF is a mental training technique.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Intervention model description

mindfulness or/and active/sham neurofeedback

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* At least 18 years old * Free of any psychiatric diagnoses or medication (besides a substance use disorder (SUD) to alcohol, tobacco, or cannabis) * In the past month, at least 4 episodes of heavy episodic drinking; at least 3 occasions of cannabis use; and daily cigarette use for at least the past month * Normal or corrected-to-normal vision * Written informed consent * No previous meditation or NF experiences

Exclusion criteria

* Any psychiatric diagnoses other than an SUD * Medical disorder(s) that may affect the central nervous system; medications that affect the central and autonomic nervous system; or a positive pregnancy test result (females) * Excluding cannabis, evidence of recent (past month) illicit drug use

Design outcomes

Primary

Measure	Time frame	Description
Intervention effects on brain function using Functional Magnetic Resonance Imaging (fMRI)	The outcome measures are assessed in-person at baseline, 2-4 weeks and 3 months	Brain connectivity changes such as anterior and posterior cingulate cortex measured by fMRI resting state imaging
Intervention effects on brain white matter using fMRI	The outcome measures are assessed in-person at baseline, 2-4 weeks and 3 months	Brain white matter changes such as anterior and posterior cingulate cortex measured by fMRI diffusion tensor imaging
Intervention effects on brain grey matter using fMRI	The outcome measures are assessed in-person at baseline, 2-4 weeks and 3 months	Brain volume changes such as anterior and posterior cingulate cortex measured by fMRI structural imaging

Secondary

Measure	Time frame	Description
Intervention effects on addiction behavior using substance use questionnaires in PhenX Toolkit	The outcome measures are assessed in-person at baseline, 2-4 weeks and 3 months	Intervention leads to a significant reduction in craving and substance use measured by substance use questionnaires in PhenX Toolkit

Countries

United States

Contacts

Primary ContactYiYuan Tang

yiyuan@asu.edu4807903577

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026