Comparison of Free-breathing 3D Quantitative Perfusion in Patients With MINOCA and MINOCA-mimics

Comparison of Free-breathing 3D Quantitative Perfusion in Patients With MINOCA, Tako-Tsubo, SCAD, Myocarditis and NSTEMI in the Acute Phase and Post Convalescence

Status

Recruiting

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT06323811

Acronym

COPE-CMR

Enrollment

Registered

2024-03-21

Start date

2023-06-15

Completion date

2025-12-31

Last updated

2024-03-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Myocardial Infarction With Non-Obstructive Coronary Artery, Myocarditis Acute, Non ST Elevation Myocardial Infarction, Spontaneous Coronary Artery Dissection, Takotsubo Cardiomyopathy

Keywords

MINOCA, MINOCA-mimics, CMR, 3D perfusion, advanced CMR imaging

Brief summary

This clinical study examines patients presenting with acute myocardial infarction and no significant coronary artery disease on coronary angiography (MINOCA) and patients with MINOCA-mimics with advanced CMR. The present study aims to: * assess the microvascular function with a novel quantitative 3D myocardial perfusion imaging approach in the acute phase and post-convalescence * refine the role and diagnostic potential of advanced quantitative CMR imaging * assess the potential prognostic significance of microvascular dysfunction and epicardial adipose tissue on cardiovascular outcomes Participants will undergo advanced CMR imaging in the acute setting (within 10 days after event) and post convalescence (after 3 months).

Detailed description

Advanced CMR includes a novel free-breathing motion-informed locally low-rank quantitative 3D myocardial perfusion imaging. Perfusion imaging will be compared with 3D late gadolinium enhancement (LGE) imaging. A cine Dixon sequence is performed for the assessment of epicardial adipose tissue (EAT).

Interventions

DIAGNOSTIC_TESTCMR

Advanced CMR imaging including a novel quantitative free-breathing 3D perfusion sequence, 3D LGE imaging and a cine Dixon sequence

Study design

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

DIAGNOSTIC

Masking

SINGLE (Investigator)

Intervention model description

5 groups of patients (MINOCA, myocarditis, Takotsubo cardiomyopathy, SCAD, NSTEMI) will undergo CMR with 3D perfusion in the acute setting (within 10 days after the event) and post convalescence (after 3 months)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* acute presentation with signs/symptoms of acute coronary syndrome or myocarditis * elevated cardiac biomarkers * no signficant coronary artery disease on coronary angiogram or coronary CT

Exclusion criteria

* pacemaker/other devices or claustrophobia * severe asthma, chronic obstructive lung or kidney disease * acute pulmonary embolism * arrhythmia on ECG * moderate to severe valvular disease

Design outcomes

Primary

Measure	Time frame	Description
Myocardial perfusion reserve index	within 10 days and after 3 months after index event	comparison of microvascular function in the acute phase versus post convalescence

Secondary

Measure	Time frame	Description
epicardial adipose tissue (EAT)	4 months (measured either at first or second CMR)	the amount of epicardial adipose tissue
cardiovascular events	5 years	rate of cardiovascular death, myocardial infarction, recurrence of MINOCA, myocarditis, takotsubo cardiomyopathy, SCAD

Countries

Switzerland

Contacts

Primary ContactRobert Manka, Prof., MD

robert.manka@usz.ch+41442551251

Backup ContactVerena C Wilzeck, MD

verena.wilzeck@usz.ch

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026