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Role of Probiotics as Adjunct Therapy Along With Standard Care in Decreasing Hospital Stay and Improving Symptoms in Pediatric Patients Admitted With Severe Pneumonia

Role of Probiotics as Adjunct Therapy Along With Standard Care in Decreasing Hospital Stay and Improving Symptoms in Pediatric Patients Admitted With Severe Pneumonia

Status
Recruiting
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT06323642
Enrollment
60
Registered
2024-03-21
Start date
2023-09-01
Completion date
2024-03-31
Last updated
2024-03-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pneumonia, Probiotics

Keywords

pneumonia treatment, probiotics

Brief summary

Probiotics as adjuvant therapy along with standard care can decrease hospital stay and improve symptoms (fever, tachypnea,cough) in pediatric patients admitted with severe pneumonia.

Detailed description

After getting written informed consent from parents/attendants, all patients aged 6 month-2yrs admitted with severe pneumonia in pediatric wards of children hospital, during the study time of 6 month will be recruited.After applying exclusion criteria remaining participants will be included in the study. The study population will be randomized in to two groups, Group A will be given probiotic sachet and group B will be given simple milk as placebo.The patients and their parents/attendants will be kept blind to the fact that they are receiving either probiotic or placebo The probiotic and placebo mixture will be given daily for three days.The patients in both the groups will be followed for the duration of illness until they are either discharged or show any adverse outcomes of pneumonia.Total days of admission will be recoded for patients discharged from hospital.Parents will be asked questions regarding improvement in symptoms like fever on discharge. Duration for Improvement in tachypnea andcough will be noted for all patients. Outcomes will be duration of hospital admission, improvement in fever, tachypnea and cough.All the data collected will be entered and analyzed using SPSS latest version and analysed.

Interventions

DIETARY_SUPPLEMENTprobiotic containing Lactobacillus rhamnosus GG.

probiotic containing Lactobacillus rhamnosus GG will be given daily for 3 days

OTHERplacebo

milk as placebo

Sponsors

Shaheed Zulfiqar Ali Bhutto Medical University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)

Masking description

The patients and their parents/attendants will be kept blind to the fact that they are receiving either probiotic or placebo

Intervention model description

randomized control trial

Eligibility

Sex/Gender
ALL
Age
6 Months to 2 Years
Healthy volunteers
No

Inclusion criteria

Patient aged 2month-24months. Both male and female children

Exclusion criteria

Patients with severe acute malnutrition Patients with very severe pneumonia Patients with Other concurrent infections Patients having any chronic debilitating condition Children who took probiotics in past 6 months Patient requiring mechanical ventilation

Design outcomes

Primary

MeasureTime frameDescription
Number of days in hospital6 monthhospital stay in patients admitted with severe pneumonia.

Secondary

MeasureTime frameDescription
Number of days with cough, fever6 monthImproving symptoms in patients admitted with severe pneumonia.

Countries

Pakistan

Contacts

Primary ContactNighat Haider
nighathaider@hotmail.com+923212125768
Backup ContactRashiqa Saadat, MBBS
rashi.bs@hotmail.com+923436568998

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026