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Direct Thawing of Vitrified Human Blastocyst

A Pilot Study on Developing a One-step Direct Thawing Method on Human Blastocysts With Transcriptomic and Methylomic Comparison to Conventional Vitrified-thawing Method

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT06322823
Enrollment
116
Registered
2024-03-21
Start date
2020-01-01
Completion date
2023-12-31
Last updated
2024-03-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

IVF

Brief summary

There are more than million frozen embryo transfers around the world each year; a faster, safer, and cheaper method can save a significant amount of money for patients undergoing IVF treatment worldwide.

Interventions

PROCEDUREdirect thawing

Vitrified blastocysts will be thawed directly into 1ml G-TL medium

PROCEDUREVitrification

Vitrified blastocysts will be thawed using commercially available one-step media.

Sponsors

Chinese University of Hong Kong
Lead SponsorOTHER

Study design

Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
SINGLE (Subject)

Eligibility

Sex/Gender
FEMALE
Healthy volunteers
Yes

Inclusion criteria

* Patients who are willing to use direct-thawed blastocysts

Exclusion criteria

* Patients who are not willing to use direct-thawed blastocysts

Design outcomes

Primary

MeasureTime frameDescription
blastocysts survival rateup to 6 monthsThe overall survival rate for thawed blastocysts using different thawing method will be compared.

Secondary

MeasureTime frameDescription
ferilization rateup to 12 monthsThe fertilization rate of frozen embryos using different thawing methods will be compared.
pregnancy rateup to 12 monthsThe pregnancy rate of patients who will be scheduled for the transfer of frozen embryos using different thawing methods will be compared.
live birth rateup to 24 monthsThe live birth rate of patients who will be scheduled for the transfer of frozen embryos using different thawing methods will be compared.

Countries

Hong Kong

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026