Dermatology
Conditions
Keywords
Skin analysis, Skin care products
Brief summary
To assess the efficacy of SOD like Super Drink on anti-oxidant capacity, immuno regulation and skin for human
Interventions
DIETARY_SUPPLEMENTSOD like Super Drink
consume 1 bottle per day
DIETARY_SUPPLEMENTplacebo drink
consume 1 bottle per day
Sponsors
TCI Co., Ltd.
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
30 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* healthy adults aged between 30-65 years old
Exclusion criteria
* Subjects who have known cosmetic, drug or food allergies, difficulty in digestive tract absorption or disorder * Patients with diseases of the skin, liver, kidney. * Female who is pregnant or nursing or planning to become pregnant during the course of the study. * Received facial laser therapy, chemical peeling or UV overexposure (\> 3 hr/week) in the past 4 weeks. * Students who are currently taking courses taught by the principal investigator of this trial.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| the change of immune-related cytokines of blood | Change from Baseline immune-related cytokines at 8 weeks | venous blood was sampled to measure immune-related cytokines |
| the roughness of skin texture | Rating skin roughness from Baseline skin texture at 8 weeks | IRV full-face skin analyzer was utilized to measure skin texture. Units: arbitrary units |
| the change of skin elasticity | Change from Baseline skin elasticity at 8 weeks | Cutometer® was utilized to measure skin elasticity. Units: arbitrary units |
| the change of Total Anti-oxidative Capacity (TAC) of blood | Change from Baseline TAC at 8 weeks | venous blood was sampled to measure TAC |
| the change of Superoxide Dismutase (SOD) of blood | Change from Baseline SOD at 8 weeks | venous blood was sampled to measure SOD |
| the change of Glutathione S-transferase (GST) of blood | Change from Baseline GST at 8 weeks | venous blood was sampled to measure GST |
| the change of Glutathione (GSH) of blood | Change from Baseline GSH at 8 weeks | venous blood was sampled to measure GSH |
| the change of Malondialdehyde (MDA) of blood | Change from Baseline MDA at 8 weeks | venous blood was sampled to measure MDA |
| the volume of skin wrinkles | Volume change from Baseline skin wrinkles at 8 weeks | IRV full-face skin analyzer was utilized to measure skin wrinkles. Units: arbitrary units |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| the change of Skin Melanin Index | Change from Baseline skin Melanin Index at 8 week | Mexameter® MX 18was utilized to measure Melanin Index. Units: arbitrary units |
| the change of skin Transepidermal Water Loss (TEWL) | Change from Baseline TEWL at 8 week | Tewameter® TM 300 was utilized to measure TEWL. Units: arbitrary units |
| the change of skin surface hydration | Change from Baseline skin surface hydration at 8 week | Corneometer® CM 825 was utilized to measure skin surface hydration. Units: arbitrary units |
| the change of Skin Erythema Index | Change from Baseline skin Erythema Index at 8 week | Mexameter® MX 18was utilized to measure skin Erythema Index. Units: arbitrary units |
Other
| Measure | Time frame | Description |
|---|---|---|
| The change of self-assessment skin condition and immuno condition | Change from Baseline skin condition and immunol condition at 8 weeks | A self-assessment questionnaire was collected to evaluate skin condition and immunol condition，As for the evalutation of skin condition ,the higher score the better；As for evaluation of immunol condition , the higher score the worse |
| The change of liver function biomarkers (AST, ALT) of blood | Change from Baseline liver function biomarkers at 8 weeks | Venous blood was sampled to measure liver function biomarkers |
| The change of renal function biomarkers (creatinine, BUN) of blood | Change from Baseline renal function biomarkers at 8 weeks | Venous blood was sampled to measure renal function biomarkers |
Countries
Taiwan
Outcome results
None listed