Invasive Bacterial Diseases (IBD)
Conditions
Brief summary
Streptococcus pneumoniae (pneumococcus), Neisseria meningitidis (meningococcus), and Haemophilus influenzae (hemophilus) are among the main bacteria responsible for invasive bacterial diseases (MBIs) that result in severe clinical pictures also characterized by a high frequency of serious complications. Surveillance of infections caused by these pathogens and their distribution by serotypes/serogroups is essential to guide public health interventions, assess epidemiologic trends, monitor any secondary cases, estimate the proportion of preventable cases, identify any vaccine failures, and evaluate the impact of vaccine strategies.The present study aims to study the epidemiology of invasive bacterial diseases, characterize the circulating strains also in order to plan treatment and prevention strategies.
Detailed description
Pathogen identification by culture methods has been shown to be unsatisfactory, as antibiotic therapy carried out in patients before hospitalization prevents bacterial culture development and subsequent typing in many cases. In addition, technical problems due to sample collection, storage and transport reduce germ viability leading to false negatives in pathogen identification by culture methods. In contrast, molecular diagnosis allows germ identification on biological samples even in the absence of germ viability, thus enabling more accurate diagnosis. Surveillance of infections caused by these pathogens and their distribution by serotypes/serogroups is essential to guide public health interventions, assess epidemiological trends, monitor any secondary cases, estimate the proportion of preventable cases, identify any vaccine failures, and evaluate the impact of vaccine strategies.In 2006, the AOU Meyer Immunology Laboratory received a grant from the National Center for Disease Prevention and Control (NCDC) to develop a molecular diagnostic method for surveillance of invasive infections with Neisseria meningitidis (meningococcal,) Streptococcus pneumoniae (pneumococcus) and Haemophilus influenzae (hemophilus) that would allow identification of the germ on biological samples even in the absence of germ viability, with a view to improving surveillance, prevention and treatment strategies. The project involved performing molecular diagnostic tests on samples from patients referred to hospitals in the Tuscany Region and outside the region. The present study aims to study the epidemiology of invasive bacterial diseases, characterize the circulating strains also in order to plan treatment and prevention strategies.
Interventions
DIAGNOSTIC_TESTassessment of pathogens in blood specimens
Molecular diagnosis of Invasive bacterial diseases due to Streptococcus pneumoniae, Neisseria meningitidis and Haemophilus influenzae
Sponsors
Meyer Children's Hospital IRCCS
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
1 Days to 70 Years
Healthy volunteers
No
Inclusion criteria
* Pediatric and adult patients diagnosed with pneumococcal, meningococcal, and hemophilus MBI
Exclusion criteria
* Other type of bacterial infections.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Incidence rate of Infective Bacterial Diseases from Streptococcus pneumoniae (pneumococcus) during the study period in pediatric age. | Through study completion, an average of 1 year | Monitor the trend of Infective Bacterial Diseases cases Streptococcus pneumoniae (pneumococcus) in Italy, during pediatric age. |
| Incidence rate of of Infective Bacterial Diseases cases from Neisseria meningitidis during the study period in pediatric age. | Through study completion, an average of 1 year | Frequencies of Infective Bacterial Diseases cases from Neisseria meningitidis in Italy (meningococcus) |
| Incidence rate of Infective Bacterial Diseases cases from Haemophilus influenzae during the study period in pediatric age. | Through study completion, an average of 1 year | Frequencies of Infective Bacterial Diseases cases from Haemophilus influenzae (hemophilus) in Italy |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Frequency of circulating serogroups/serotypes in Italy for S.pneumoniae, N.meningitidis, H.influenzae. | Through study completion, an average of 1 year | Describe the distribution of circulating serogroups/serotypes |
| Proportion of these invasive infections (S.pneumoniae, N.meningitidis, H.influenzae) that are preventable by vaccine in Italy | Through study completion, an average of 1 yeary | Estimate the proportion of these invasive infections that are preventable by vaccine |
| Vaccine failure rate for S.pneumoniae, N.meningitidis, and H.influenzae. | Through study completion, an average of 1 year | Assessing rate cases of vaccine failure |
Countries
Italy
Contacts
Primary ContactChiara Azzari, MD
Outcome results
None listed