Acute Coronary Syndrome, Heart Failure With Reduced Ejection Fraction
Conditions
Brief summary
Investigators evaluate whether differences exsit in acute coronary syndrome（ACS） patients with ejection \<45% between participants who take vericiguat regularly and those who donot.
Detailed description
Vericiguat, a novel soluble guanylate cyclase stimulator, reduced the incidence of cardiovascular death or hospitalization for HF in a population of high-risk patients with heart failure with reduced ejection fraction （HFrEF ）who had recently been hospitalized or received intravenous diuretic therapy.Given the increasing incidence of patients with ACS and its challenges posing to life，investigators intend to conduct a prospective observational study. Investigators choose several meaningful endpoints including the time of cardiovascular death or heart failure（HF) hospitalization、inflammatory markers、the value of N-terminal pro-B-type natriuretic peptide(NT-proBNP)、results of echocardiogram and life quality score.By collecting these datas and work on a group of analysis ，investigators evaluate whether differences exsit in ACS patients with ejection \<45% between participants who take vericiguat regularly and those who donot.
Interventions
None listed
Sponsors
The First Affiliated Hospital with Nanjing Medical University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* 1.Provide written informed consent for the trial. * 2.Has acute coronary syndrome (unstable angina, non-ST elevation myocardial infarction \[NSTEMI\], or ST elevation myocardial infarction \[STEMI\]) or coronary revascularization (coronary artery bypass grafting \[CABG\] or percutaneous coronary intervention \[PCI\]). * 3.ejection fraction \<45%. * 4.Be male or female, aged greater than18 and less than 90 on the day of signing informed consent.
Exclusion criteria
. * 1.SBP\<100mmHg. * 2.Is pregnant or breastfeeding or plans to become pregnant or to breastfeed during the course of the trial. * 3.Has severe hepatic insufficiency or renal insufficiency. * 4.Has malignancy or other non-cardiac condition limiting life expectancy to \<1 years.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| a composite of death from cardiovascular causes or first hospitalization for heart failure | from baseline to one year |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| results of echocardiogram | from baseline to one year | changes in left ventricular ejection fraction during the follow-up |
| the numerical value of NT-proBNP | from baseline to one year | an important biomarker of heart failure |
| life quality score | from baseline to one year | Investigators choose Kansas City Cardiomyopathy Questionnaire(KCCQ) to evaluate life quality of participants. |
Countries
China
Outcome results
None listed