Immune Function of Colorectal Cancer Lymph Nodes

A Multiomics-based Study of the Immune Function of Colorectal Cancer Lymph Nodes

Status

Not yet recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06319404

Enrollment

500

Registered

2024-03-20

Start date

2024-04-01

Completion date

2026-04-01

Last updated

2024-03-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Colorectal Cancer, Lymph Node

Brief summary

Lymph nodes are very important immune organs in the human body and play an important role in the physiological and pathological activities of the body, especially in anti-tumor immunity. The role of regional draining lymph nodes in the development of colorectal cancer is still unknown. In this study, the role of lymph nodes in the development of colorectal cancer was investigated through multicenter and multi-omics data.

Interventions

None listed

Study design

Observational model

OTHER

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 75 Years

Inclusion criteria

* Stage I-III colorectal cancer patients undergoing radical surgery * Complete imaging, pathology and genetics multi-omics data available * 18-75 years old

Exclusion criteria

* Patients with preoperative neoadjuvant therapy * Patients with incomplete clinical information * Patients with other malignant tumors * Patients with acute infections or untreated chronic infections

Design outcomes

Primary

Measure	Time frame	Description
To investigate the relationship between the type and number of immune cells in tumor draining lymph nodes and the activation of immune pathways is based on pathomics	2024.04-2026.04	Multiple immunohistochemistry was used to identify the type and number of immune cells and to explore the relationship between the activation state of immune pathways
To investigate the difference of immune pathway activation in tumor-draining lymph node based on genomics	2024.04-2026.04	BULK-RNA sequencing was performed on tumor draining lymph nodes to detect the activation of immune pathways in lymph nodes and explore the differences between them
The immune function of tumor draining lymph nodes of colorectal cancer patients was previously identified based on radiomics	2024.04-2026.04	Preoperative imaging data (CT, MRI) of patients were collected, and information in the images was extracted based on artificial intelligence algorithms. Predictive models were constructed to identify patients with good or bad immune function before surgery and guide subsequent treatment

Contacts

Primary ContactXu Guan

drguanxu@163.com13141307719

Outcome results