Insulin Resistance, Postoperative Nausea and Vomiting, Quality of Recovery, Dizzyness
Conditions
Keywords
Glucose injection Solution, PONV
Brief summary
The aim of this study was to determine the effect of intravenous infusion of 5% dextrose injection during the recovery period of anesthesia for painless gastroenteroscopy on the patient's blood glucose level, incidence of hypoglycemia and time of awakening from anesthesia, postoperative vertigo, postoperative nausea and vomiting, and quality of recovery in the early postoperative period.
Interventions
OTHER5% glucose
Patients in the experimental group were infused intravenously with 5% dextrose (500 ml/h) in the PACU.
Patients in the control group were infused intravenously with 0.9% sodium chloride solution in the PACU.
Sponsors
Weifang Medical University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
TRIPLE (Subject, Caregiver, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 79 Years
Healthy volunteers
No
Inclusion criteria
1. patients who meet the indications for painless gastrointestinal endoscopy and are aged 18 to 79 years. 2. The patient or his/her guardian or immediate family members gave informed consent; 3. American Society of Anesthesiology (ASA) anesthesia risk classification ≤ grade III.
Exclusion criteria
1. Patients with contraindications to sedation/anesthesia for gastrointestinal endoscopy: e.g., severe hepatic and renal dysfunction, cardiac insufficiency; 2. Patients receiving chemotherapy and opioid treatment; patients with a history of sleep apnea hypoventilation syndrome; 3. Intravenous nutritional support within 8 hours prior to the examination; 4. Patients diagnosed with type I or type II diabetes.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Preoperative blood glucose 30min | Measurements taken 0.5 hours Preoperative. | A fingertip blood glucose concentration of \<3.9 mmol/L was used as a diagnostic criterion for hypoglycemia. Severity and incidence of hypoglycemia at 0.5 hours Preoperative. |
| Postoperative blood glucose 2h | Measured at 2 hours postoperatively. | A fingertip blood glucose concentration of \<3.9 mmol/L was used as a diagnostic criterion for hypoglycemia. Severity and incidence of hypoglycemia at 2 hours postoperatively. |
| Dizziness level | Approximately 15min after surgery | The Visual Analogue Scale(VAS) was used to assess the degree of postoperative dizziness in patients undergoing painless gastroenteroscopy. |
| Postoperative nausea and vomiting | Measured at 0.5 hours postoperatively. | The Index of Nausea and Vomiting and Retching (INVR) was used in this study. The scale consists of 8 items with 3 dimensions, which can quantify the number of occurrences, duration and severity of symptoms. The scale is scored using the Likert method, with a total of 32 points on a 5-point scale ranging from 0 to 4. The higher the score, the more severe the symptoms of nausea, vomiting, and dry heaving (entries 1, 6, and 7 are reverse scored). According to the score, nausea, vomiting and dry heaving symptoms can be categorized into five grades: 0, I, II, III and IV, and grade ≥I means that the symptom occurs. The severity and incidence of PONV at 0.5 hours postoperatively. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Anesthesia awakening time | Approximately 30min after surgery | The clinical routine defines the time of awakening from anesthesia as the time between the cessation of anesthesia administration and the opening of the patient's eyes on call. |
| Quality of postoperative recovery (QoR40) | Approximately 24hours after surgery | The QoR-40 scale provides a true and valid reflection of the impact of various factors on the quality of postoperative recovery. |
Countries
China
Outcome results
None listed