Nanofat Versus Platelet Poor Plasma Gel for Infraorbital Rejuvenation

Status

Completed

Phases

Phase 1

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT06318091

Enrollment

Registered

2024-03-19

Start date

2021-06-01

Completion date

2023-06-01

Last updated

2024-03-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Tear Trough Eyelid Deformity

Keywords

platelet poor plasma gel, nanofat, infraorbital rejuvenation

Brief summary

this study was conducted for evaluation of the clinical efficacy, safety, and potential side effects of platelet poor plasma gel versus nonfat injection in infraorbital rejuvenation

Interventions

BIOLOGICALnanofat

injection of nanofat in the dark circles around the eye to rejuvenate and improve pigmentation

BIOLOGICALplatelet poor plasma gel

injection of platelet poor plasma gel in the dark circles around the eye to rejuvenate and improve pigmentation

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

* all patients with infraorbital dark circles

Exclusion criteria

* pregnancy * breast feeding * infectious disorders

Design outcomes

Primary

Measure	Time frame	Description
the degree of changes in the skin texture and homogeneity	3 months	the degree of changes in the skin texture and homogeneity was assessed using the five grades scale according to percentage of change in skin surface smoothness and color uniformity (1: much worse if deterioration \>25%, 2: worse if deterioration \<25%, 3: slightly improved if improvement \<25%, 4: improved if improvement = 25%-50%, and 5: greatly improved if improvement \>50%).

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026