Cortical Contact, Soft Tissue Sarcoma
Conditions
Brief summary
the purpose of this study is to assess whether bone resection for thigh soft tissue sarcoma with cortical involvement of the adjacent bone result in better local control and survival compared to sub-periosteal dissection. Investigators also aim to find out the prognostic factors for clinical outcomes in this group of patients.
Interventions
PROCEDUREbone resection
patients underwent soft tissue sarcoma excision together with bone resection following either biological or endoprosthesis reconstruction
PROCEDUREsubperiosteal excision
patients underwent sub-periosteal tumor excision combining bone and soft tissue ablation without bone excision
Sponsors
Second Affiliated Hospital, School of Medicine, Zhejiang University
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
8 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
1. Patients developed thigh soft tissue sarcoma, defined as lesion located below the plane of the lesser trochanter and above the plane of the femoral condyle. 2. received primary limb-salvage surgery at our center. 3. soft tissue sarcoma with only cortical contact of the adjacent bone based on preoperative imaging 4. minimum of 2-year follow up
Exclusion criteria
1. diagnosis was well differentiated liposarcoma 2. patients with metastatic disease at the time of presentation 3. soft tissue sarcoma displayed frank osseous invasion (eg. medullary canal invasion)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| survival | patients were checked every three months for the initial two years after surgery and every 6 months for the subsequent three years. After 5 years, patients will be checked once every year until patients died or were loss to follow up. | Whether patient die or not |
| recurrence | patients were checked every three months for the initial two years after surgery and every 6 months for the subsequent three years. After 5 years, patients will be checked once every year until patients died or were oss to follow up. | whether patients developed local recurrence |
| metastasis | patients were checked every three months for the initial two years after surgery and every 6 months for the subsequent three years. After 5 years, patients will be checked once every year until they died or were loss to follow up. | whether patients developed metastasis |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| functional outcomes | MSTS scores were measured every 6 months for the first two years after surgery. After that, MSTS outcomes were measured once every year until patients died or were loss to follow up. | The Musculoskeletal Tumor Society (MSTS) questionnaire for the lower extremity is composed of six items including pain, function, emotional acceptance, use of any external support, walking ability, and gait alteration. Each item is rated in a scale of 0-5. The total score ranges from 0 to 30, with higher scores indicating better function. |
Outcome results
None listed