Diabetes Mellitus, Type 1
Conditions
Keywords
Type 1 diabetes, Metabolic control
Brief summary
A good metabolic control of type 1 diabetes mellitus (T1DM) is crucial to avoid long-term complications associated with the disease. Although recent evidences suggest that a good metabolic control of T1DM is partly independent of management intensity and could be anticipated since onset, factors that influence glycated haemoglobin (HbA1c) patterns remain poorly understood and are likely to be genetic. While significant progress has been made in understanding of the genetic contribution to T1DM onset, very few studies have evaluated the role of genetic factors on T1DM metabolic control. This study aims to create a comprehensive database of genetic and phenotypic data in a cohort of children and young adults with T1DM and to evaluate genetic and environmental factors that might predict trajectories in glycemic control
Interventions
DIAGNOSTIC_TESTBlood and saliva analysis
Phenotyping and genotyping characterization using blood and saliva
Sponsors
IRCCS Burlo Garofolo
Study design
Observational model
OTHER
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
6 Years to 21 Years
Healthy volunteers
No
Inclusion criteria
Cases: * age between 6 and 21 years; * patients suffering from type 1 diabetes Controls: * age between 6 and 21 years; * patients for whom a venous sampling is planned
Exclusion criteria
Cases: * patients for whom it is not possible to collect information on the clinical history, starting from the onset of diabetes * patients with other types of diabetes mellitus (type 2, monogenic diabetes, diabetes related to cystic fibrosis...) * patients incapable of expressing valid informed consent or whose parents are incapable of expressing valid informed consent. Controls: * subjects with type 1 and 2 diabetes * obese subjects and those with a family history of diabetes and obesity or other metabolic disorders * subjects with HbA1c \>6% * patients incapable of expressing valid informed consent or whose parents are incapable of expressing valid informed consent.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Identification of environmental factors affecting T1DM metabolic control | Through study completion, an average of 18 months | — |
| Identification of genetic factors affecting T1DM metabolic control | Through study completion, an average of 18 months | Identify genetic factors responsible of differences in T1DM metabolic control and thus uncover genes of potential biological therapeutic importance |
Countries
Italy
Contacts
Primary ContactAntonietta Robino
Backup ContactGianluca Tornese, MD Phd
Outcome results
None listed