Papillary Thyroid Cancer
Conditions
Brief summary
1. To evaluate the clinical outcomes of ultrasound-guided thermal ablation and thyroid surgery for the treatment of papillary thyroid carcinoma; 2. To develop and validate a artificial intelligence model to predict the outcomes of ultrasound-guided thermal ablation in the treatment of papillary thyroid carcinoma;
Interventions
PROCEDUREthyroid surgery
thyroid lobectomy
PROCEDUREultrasound-guided thermal ablation
radiofrequency ablation; microwave ablation or laser ablation
Sponsors
Chinese PLA General Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
1. patients age between 18 and 80 year old, both sex 2. papillary thyroid carcinoma confirmed by core-needle biopsy or fine-needle aspiration 3. the largest diameter ≤2.0 cm 4. no clinical or imaging evidences of extrathyroidal extension, lymph node metastasis and distant metastasis on ultrasound, nech and chest CT 5. follow-up period ≥12 months,
Exclusion criteria
1. patients with convincing evidence of aggressive papillary thyroid carcinoma or other type of thyroid cancer by biopsy 2. history of neck radiation 3. history of thyroid surgery 4. coagulation disorder 5. serious heart, respiratory, liver, or renal failure 6. dysfunction of the vocal cord on the opposite side
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| rate of disease progression | more than 5 year | cervical lymph node metastases, recurrent tumors and persistent tumors |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Rate of complications | 1week | surgery or ablation complications |
| Rate of tumor disappearance | 2 year | complete disappearance of ablated tumor on ultrasound and contrast-enhanced ultrasound |
Countries
China
Contacts
CONTACTLin Yan, MD
STUDY_CHAIRYukun Luo
Chinese PLA General Hospital
Outcome results
None listed