The Use of Nomegestrol Acetate/Estradiol in Random Start Rapid Endometrial Preparation

The Use of Nomegestrol Acetate/Estradiol in Random Start Rapid Preparation of Endometrium Before Office Hysteroscopic Polypectomies: a Multicenter, Prospective, Randomized Study

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT06316219

Enrollment

Registered

2024-03-18

Start date

2023-01-01

Completion date

2024-03-01

Last updated

2024-04-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Endometrial Diseases, Endometrial Polyp

Keywords

Hysteroscopy, Endometrial preparation

Brief summary

The presence of a thin endometrium plays an important role in enabling the best conditions for hysteroscopic surgery. Recently, for this purpose, many studies have evaluated the effect of preoperative administration of a variety of drugs. We explored the efficacy of random started 14-day administration of Nomegestrol Acetate/Estradiol, in rapid preparation of endometrium for hysteroscopic polypectomy.

Interventions

DRUGNomegestrol Acetate/Estradiol 2.5mg/1.5mg

hysteroscopic polipectomy after starting 14-day treatment with oral Nomegestrol Acetate/Estradiol 2.5mg/1.5mg at any time of the menstrual cycle

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

FEMALE

Healthy volunteers

Yes

Inclusion criteria

* Patients with endometrial polyps.

Exclusion criteria

* Patients with other endometrial pathologies.

Design outcomes

Primary

Measure	Time frame	Description
Quality of endometrial preparation	14th day of treatment	Quality of endometrial preparation assessed visually intraoperatively by the surgeon using a visual analog scale from 0 to 5.

Countries

Italy

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026