The Use of Drospirenone/Estetrol in Random Start Rapid Endometrial Preparation

The Use of Drospirenone/Estetrol in Random Start Rapid Preparation of Endometrium Before Office Hysteroscopic Polypectomies: a Multicenter, Prospective, Randomized Study

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT06316180

Enrollment

Registered

2024-03-18

Start date

2023-01-01

Completion date

2024-03-01

Last updated

2024-04-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Endometrial Diseases, Endometrial Polyp

Keywords

Hysteroscopy, Endometrial Preparation

Brief summary

The presence of a thin endometrium plays an important role in enabling the best conditions for hysteroscopic surgery. Recently, for this purpose, many studies have evaluated the effect of preoperative administration of a variety of drugs. We explored the efficacy of random started 14-day administration of drospirenone/estetrol, in rapid preparation of endometrium for hysteroscopic polypectomy.

Interventions

DRUGdrospirenone/estetrol 3mg/14.2mg

Hysteroscopic polipectomy after starting 14-day treatment with oral drospirenone/estetrol 3mg/14.2mg at any time of the menstrual cycle.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

FEMALE

Healthy volunteers

Yes

Inclusion criteria

* Patients with endometrial polyps.

Exclusion criteria

* Patients with other endometrial pathologies.

Design outcomes

Primary

Measure	Time frame	Description
Quality of endometrial preparation	Intraoperatively	Quality of endometrial preparation assessed visually intraoperatively by the surgeon using a visual analog scale from 0 to 5.

Countries

Italy

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026