Membranous Nephropathy, Minimal Change Disease, Nephrotic Syndrome, Primary Focal Segmental Glomerulosclerosis
Conditions
Brief summary
A prospective observational study to investigate the treatment-associated changes of circulating factors associated with glomerular diseases among patients with de novo nephrotic syndrome admitted to hospital for a kidney biopsy.
Interventions
OTHERObservation
Observation
Sponsors
Iain Bressendorff
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Inclusion criteria
* Age ≥ 18 years * Plasma albumin \< 36 g/L * Urine protein \>3.5 g/day or urine protein/creatinine-ratio (UPCR) \> 3.5 or urine albumin/creatinine-ratio (UACR) \>2200 mg/g * Planned kidney biopsy * Able to give written informed consent
Exclusion criteria
* Kidney transplant recipient * Previously undergone a kidney biopsy * Unable to understand written information in Danish
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| levels of anti-nephrin in blood by ELISA | up to 12 months | temporal association of anti-nephrin with clinical remission of nephrotic syndrome |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| changes in auto-antibodies in blood associated with membranous nephropathy | up to 24 months | temporal association of auto-antibodies with clinical remission of nephrotic syndrome |
Contacts
Primary ContactIain Bressendorff, MD PhD
Backup ContactDitte Hansen, MD PhD
Outcome results
None listed