Pregnancy
Conditions
Keywords
Placenta, MRI, BMI, Weight
Brief summary
The purpose of this study is to evaluate the flow of oxygen and blood necessary for nutrient transfer across the placenta during the second and third trimesters in pregnancy in women who are obese before pregnancy compared to women who have an average weight before pregnancy. This study will evaluate blood flow across the placenta by functional Magnetic Resonance Imaging (fMRI). The investigators hypothesize that there will be differences in placental oxygenation and blood flow among women with obesity as compared to those with normal weight. Participants will be asked to complete: * MRI in the second trimester (20-24 weeks) * MRI in the third trimester (30-34 weeks)
Interventions
DIAGNOSTIC_TESTfunctional Magnetic Resonance Imaging (fMRI)
Participants will undergo a functional Magnetic Resonance Imaging (fMRI) using arterial spin labeling (ASL) and other Magnetic Resonance (MR) sequences
Sponsors
Endeavor Health
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* Singleton pregnancy, less than 24 weeks gestation * Pre-pregnancy BMI between 18.5 - 24.9kg/m2 or ≥30kg/m2
Exclusion criteria
* Asthma on controller medication * Autoimmune Conditions * Chronic Hypertension * Claustrophobia * Congenital Anomaly * Pregestational Diabetes * History of Bariatric Surgery * HIV * Ineligible for MRI (incompatible implanted medical device) * Multifetal Gestation * Smoking during pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Inter - rater reliability of assessing placental blood flow by arterial spin labeling (ASL) | 6 weeks after the delivery | Evaluated using a two-way mixed intraclass correlation coefficient for consistency |
| Mean placental perfusion in second and third trimester | 6 weeks after the delivery | The mean global placental perfusion of second and third-trimester placentas among participants with obesity (Body Mass Index measured in kg/m\^2, calculated using weight in kilograms and height in meters) as compared to those with a normal weight (kilograms) before pregnancy will be evaluated. |
| Mean R2* relaxation rates in second and third trimester | 6 weeks after the delivery | the Mean R2\* relaxation rates will be used to correlate the global placental perfusion of second and third trimester placentas with measurements of placental oxygenation. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Perinatal outcomes including hypertensive disorders of pregnancy, gestational diabetes, preterm birth, small for gestational age, NICU admission, and stillbirth. | 6 weeks after the delivery | The prevalence and incidence of outcomes such as hypertensive disorders of pregnancy, gestational diabetes, preterm birth, small for gestational age, NICU (Neonatal Intensive Care Unit) admission, stillbirth will be assessed. |
Countries
United States
Contacts
CONTACTAlexandra Mangus
CONTACTCaitlin A MacGregor, MD
PRINCIPAL_INVESTIGATORCaitlin MacGregor
Endeavor Health
Outcome results
None listed