Chronic Hepatitis B
Conditions
Brief summary
The goal of this retrospective observational study is to find out the effects of probiotics on HBV clearance. The main question it aims to answer is: Are the probiotics have an effect in promoting HBV clearance? The participants will observe the HBV clearance rate in chronic hepatitis B patients receive probiotics in addition to the routine antiviral therapy. Researchers will compare the HBV clearance rate in chronic hepatitis B patients receive probiotics and antiviral therapy with those receiving solely antiviral therapy.
Interventions
DRUGPegIFNα2b+probiotics
The patients receive both PegIFNα2b and probiotics therapy
DRUGPegIFNα2b
The patients receive PegIFNα2b therapy
DRUGNucleoside analog
The patients receive nucleoside analog therapy
DRUGNucleoside analog+probiotics
The patients receive both nucleoside analog and probiotics therapy
Sponsors
Qilu Hospital of Shandong University
Study design
Observational model
CASE_ONLY
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* chronic hepatitis B patients
Exclusion criteria
* patients with malignancies * patients with other liver diseases * pregnancy patients
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HBsAg clearance | 48 months |
Countries
China
Contacts
Primary ContactYu-Chen Fan
Outcome results
None listed