Esophageal Cancer
Conditions
Keywords
Embolization, Ischemic conditioning, Esophagectomy, Lewis Santy, Anastomotic leakage
Brief summary
This retrospective monocentric comparative study aims to assess the efficacy of preoperative ischemic conditioning, in preventing anastomotic leakage in esophageal cancer surgery. Two groups were included : a surgery-alone group (control group) and a PreopAE group (study group) treated with an embolization procedure before esophagectomy. Collected data included patient characteristics, embolization procedure details, surgical outcomes, and postoperative complications. The primary outcome was the efficacy of preoperative ischemic conditioning in preventing anastomotic leakage, assessed through CT scans. Secondary outcomes included analyzing safety of ischemic gastric conditioning, hypertrophy of the gastroepiploic artery in embolized patients and comparing hospital stay length and postoperative mortality.
Interventions
Collecting data from the medical record: * Gastroepiploic artery diameter before and after ischaemic preconditioning * Postoperative mortality * Complications related to embolisation and surgery * Length of stay in intensive care unit and total length of hospital stay
Sponsors
Centre Hospitalier Universitaire de Saint Etienne
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Inclusion criteria
* All patients older than 18 years with an indication for surgical esophagectomy with cervical anastomosis using the Lewis Santy technique or three stages approach.
Exclusion criteria
* Esophagectomy for ischemic or caustic oesophagitis, and patients lost for follow-up.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Measurement of the effectiveness of preoperative ischaemic conditioning in reducing anastomotic leakage in patients undergoing oesophagectomy. | Day : 90 | Radiological confirmation by thoracoabdominal CT scan with oral contrast showing dehiscence of the oesophagastric anastomosis will be sought. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Measurement of the effectiveness of preoperative ischaemic conditioning in reducing anastomotic leakage in patients undergoing oesophagectomy. | Day : 90 | Dehiscence confirmed by the surgeon during a repeat operation will be sought. |
| Safety of ischemic gastric conditioning | Day : 90 | Safety of ischaemic gastric filling will be analysed on the basis of imaging and data recordings. |
| Hypertrophy of the gastroepiploic artery | Day : 90 | Hypertrophy of the gastroepiploic artery in embolized patients will be analysed on the basis of imaging and data recordings. |
| Comparing hospital stay length | Day : 90 | Hospital stay length will be analysed on the basis of data recordings. |
| Comparing postoperative mortality | Day : 90 | Postoperative mortality will be analysed on the basis of data recordings. |
Countries
France
Contacts
Primary ContactRémi GRANGE, MD
Backup ContactSylvain GRANGE, MD
Outcome results
None listed