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Perioperative Factors and Living Donor Liver Transplantation

The Study on Perioperative Factors Affecting Postoperative Outcomes in Patients Who Underwent Adult Liver Transplantation

Status
Not yet recruiting
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT06312098
Enrollment
533
Registered
2024-03-15
Start date
2024-04-01
Completion date
2024-07-01
Last updated
2024-03-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Liver Transplant Disorder

Brief summary

Liver transplant surgery is one of the treatments provided to patients suffering from end-stage liver disease, and has a successful treatment prognosis. However, it is clear that patient management before, during, and after surgery is a difficult task for medical staff due to the complex clinical and pathological problems of end-stage liver disease. Moreover, the complex surgical technique of the liver transplant surgery itself and the severe hemodynamic fluctuations and multi-organ dysfunction that patients experience during the surgery have been shown to have a tremendous impact on the patient's prognosis after surgery. A study on which clinical, laboratory, and hemodynamic factors experienced by patients during the perioperative period, including before, during, and after surgery, affect the survival rate of patients and transplanted organs. will definitely be helpful in the treatment of patients suffering from end-stage liver disease.

Interventions

OTHERremote ischemic preconditioning (RIPC)

After induction of anesthesia, the paired RIPC group took the RIPC intervention on the upper arm in the lateral position. The RIPC intervention was applied using a manual cuff inflator, which consisted of three cycles of 5-min inflation of the blood pressure cuff (to 250 mmHg, or to 50 mmHg higher than the preoperative SBP), followed by 5-min deflation of the cuff. In the no-RIPC group, a blood pressure cuff was also applied on the upper arm but was not inflated.

Sponsors

Min Suk Chae
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
RETROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
19 Years to 79 Years
Healthy volunteers
No

Inclusion criteria

* adults * elective surgery * American Society of Anesthesiologists (ASA) physical status classification system I, II, III

Exclusion criteria

* American Society of Anesthesiologists (ASA) physical status classification system IV, V

Design outcomes

Primary

MeasureTime frameDescription
Incidence of postreperfusion syndromeduring surgerymean blood pressure decreases by 30% based on the value on preoperative day

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026