Optimising CMR Scan Acquisitions for Novel Equipment/Sequences in Clinical Cardiovascular Populations.

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06311552

Acronym

OPTMISE-HFpEF

Enrollment

Registered

2024-03-15

Start date

2022-01-31

Completion date

2023-11-30

Last updated

2024-03-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Heart Failure With Preserved Ejection Fraction

Brief summary

The purpose of this study is to develop robust protocols for the optimisation of novel hardware, software and exercise equipment in the magnetic resonance imaging (MRI) environment in various cohorts with cardiovascular disease (CVD) with the first study focusing on those with established heart failure with preserved ejection fraction (HFpEF) or those at risk of or with pre-HFpEF.

Interventions

OTHERParticipants will undergo a comprehensive CMR scan on either a 1.5- or 3-Tesla scanner

Participants will undergo a comprehensive CMR scan on either a 1.5- or 3-Tesla scanner

Study design

Observational model

COHORT

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to 100 Years

Healthy volunteers

Inclusion criteria

* Males or females aged \>18 years * Either a clinical diagnosis of HFpEF, be at risk of or pre- HFpEF

Exclusion criteria

* Absolute contraindication to MRI * Unable to read/understand English sufficiently to provide informed consent * Pregnancy * Unable to consent due to lack of mental capacity * Current cancer diagnosis and actively undergoing treatment * Inability to exercise on the MRI ergometer * Severe claustrophobia

Design outcomes

Primary

Measure	Time frame
To develop CMR scanning protocols which acquire the highest quality images during incremental exercise using a stepper ergometer (Ergospect Cardio-stepper).	By end of study - 30/04/2023

Secondary

Measure	Time frame
To determine the reproducibility of the exercise CMR protocols in a test-retest reproducibility sub-study	By end of study - 30/04/2023
To determine the optimal scan acquisition protocol for Magnetic Resonance Spectroscopy (MRS) both H+ and 31P using the phosphorous coil in each patient group.	By end of study - 30/04/2023
To determine the reproducibility of the MRS protocols in a test-retest reproducibility sub-study	By end of study - 30/04/2023

Countries

United Kingdom

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026