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Endoscopic Submucosal Resection Turbinoplasty VS Turbinectomy

A Comparative Study of Endoscopic Submucosal Resection Turbinoplasty and Partial Inferior Turbinectomy for Management of Inferior Turbinate Hypertrophy

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT06310083
Enrollment
40
Registered
2024-03-15
Start date
2023-02-01
Completion date
2024-01-31
Last updated
2024-03-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Turbinate; Hypertrophy Mucous Membrane

Keywords

turbinoplasty, Turbinectomy, Turbinate Hypertrophy, Endoscopy

Brief summary

The aim of our study is to compare endoscopic submucosal resection Turbinoplasty and partial inferior turbinectomy regarding clinical and radiological evaluation and its possible complications in the treatment of Chronic inferior turbinate hypertrophy.

Detailed description

The inferior turbinate (IT) plays a vital function in nose physiology by regulating the temperature and humidity of inhaled air and filtering foreign particles through the mucociliary clearance system. One of the most common manifestations of chronic rhinitis is nasal obstruction. Nasal obstruction occurs as a result of submucosal or mucosal hypertrophy associated with increased vascularity of the inferior turbinate. The location, size, and vasoactive capabilities of the inferior turbinate relegate it as a key player in airway resistance. Multiple pathologic processes may alter the gross and microscopic structure of the inferior turbinates, including septal deviation and inflammatory disorders such as allergic rhinitis, nonallergic rhinitis, and chronic rhinosinusitis. These disorders in turn lead to histological differences in terms of hypertrophy and hyperplasia, distorted cilia, inflammatory cell infiltrates, and mucosal thickening with subsequent macroscopic changes and symptomatic obstruction. Surgical reduction of the inferior turbinate is warranted to relieve the nasal block caused by the hypertrophied inferior turbinates. Surgical reduction of the inferior turbinate involves removal of the mucosa, soft erectile tissue, and turbinate bone. Different techniques have been applied to increase the nasal airway passage, such as conventional turbinectomy, laser turbinectomy, cryoturbinectomy, electrocautery turbinectomy, conventional Turbinoplasty, microdebrider Turbinoplasty, coblation Turbinoplasty, radiofrequency Turbinoplasty, and ultrasound Turbinoplasty. Conventional turbinectomy (total or partial) is considered very effective in relieving nasal block. Due to the excessive loss of tissue (bone and mucosa), the postoperative complications include excessive bleeding requiring blood transfusion, crusting, pain, and prolonged recovery period. Hence, a more mucosal-friendly approach is preferred; the Turbinoplasty procedure, which resects either soft tissue or bone or both with preservation of the mucosa. Conventional Turbinoplasty is designed to remove the nonfunctional obstructive part of the turbinate while preserving the functional medial mucosa, which plays the key role in the warming and humidification of air through the nasal passages. Performed endoscopically, inferior Turbinoplasty has the advantage over the other turbinate procedures by preserving sufficient mucosa, while removing adequate obstructed tissue to improve the airway significantly. The other term used for this technique is submucosal resection, as a reference to its submucosal dissection procedure.

Interventions

PROCEDURESubmucosal Resection Turbinoplasty Versus Partial Inferior Turbinectomy

The study's Participants Were Randomly classified in two groups Interventional Group, applied for Submucosal Resection Turbinoplasty and the controlled group who were applied for Partial Inferior Turbinectomy

Sponsors

Ahmed Nabil Selim
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Masking description

The surgeons performed the nasal surgery and evaluating postoperative measurable outcomes was blinded about cases who were subjected to Endoscopic submucosal resection Turbinoplasty

Intervention model description

A total of 40 patients were enrolled in the study. The patients were randomly classified into two groups, with 20 in each group. Group A (study group): who applied for Endoscopic submucosal resection Turbinoplasty. Group B (control group): Who applied for partial inferior turbinectomy.

Eligibility

Sex/Gender
ALL
Age
18 Years to 45 Years
Healthy volunteers
No

Inclusion criteria

* All patients aged between 18 and 45 years complaining with a minimum 3-month duration of nasal obstruction combined with clinical findings of inferior turbinate hypertrophy

Exclusion criteria

1. Patient's Hemoglobin levels are less than 10gm%. 2. Patients who were Presented with acute upper respiratory tract infection. 3. Patients with other causes of nasal obstruction, e.g.,- allergic nasal polyposis, deviated nasal septum. 4. Patients who have nasal tumors. 5. Patients who had nasal operations before 6. Presence of bleeding disorder. 7. Presence of uncontrolled systemic disease. 8. During the period of menses

Design outcomes

Primary

MeasureTime frameDescription
Nasal Obstruction3 monthsquestionnaire entitled Nasal Obstruction Syndrome Evaluation, known as NOSE score is used to evaluate the improvement in nasal obstruction This score has 5 questions about life quality. Each receives a score from 0 to 4 and these are summed up and multiplied by 20. The total NOSE score ranges from 0 to 100
Crustations3 monthsan endoscopic score of Lund and Kennedy is used to evaluate postoperative Crustations Grade 0 Absence of crustations Grade 1 Mild crustations: partially filling the nasal cavity Grade 2 Severe crustations: fully filling the nasal cavity
Nasal Discharge3 monthsrhinorrhea conventional visual analogue scale (VAS) is used to evaluate nasal Discharge. Patients were asked to rank their symptoms on a scale of 0-10, with 0 denoting no symptoms and 10 denoting the most severe symptoms, with mild symptoms scoring 0-3, moderate symptoms scoring 4-7, and severe symptoms scoring 8-10

Secondary

MeasureTime frameDescription
Duration of operation (Minutes )intraoperativeMeasurement the duration of operation by Minutes
intra operative blood lossintraoperativeBoezaart surgical field grading scale is used to evaluate intra-operative bleeding (primary), Grade 1 Minimal bleeding, no suction is needed Grade 2 Minimal bleeding, occasional suction is needed Grade 3 Slight bleeding, frequent suction is needed, and surgical field is threatened by bleeding a few seconds after removal of suction Grade 4 Bleeding is moderate, frequent suction is needed, and the surgical field is threatened by bleeding immediately after removal of suction Grade 5 Bleeding is severe, persistent suction is needed, and the surgical field is severely threatened by bleeding that cannot be controlled by suction
Hyposmia3 monthspercentage of patients whose Complaint ( Hyposmia ) Was improved postoperatively

Other

MeasureTime frameDescription
Size Of Posterior part of TurbinateBaseline ; 3 monthsComputed Tomography measurements of posterior part of turbinate pre and postoperatively
Space of posterior nasal CavityBaseline ; 3 monthsComputed Tomography measurements of posterior part of nasal Cavity pre and postoperatively
Space of Anterior nasal CavityBaseline ; 3 monthsComputed Tomography measurements of Anterior part of nasal Cavity pre and postoperatively
Size Of Anterior part of TurbinateBaseline ; 3 monthsComputed Tomography measurements of Anterior part of turbinate pre and postoperatively

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 6, 2026