Provocative Tests for HFpEF

Provocative Tests for Diagnosing and Phenotyping Heart Failure With Preserved Ejection Fraction

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06309550

Acronym

TEST-PEF

Enrollment

500

Registered

2024-03-13

Start date

2023-03-10

Completion date

2028-03-31

Last updated

2025-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Heart Failure With Preserved Ejection Fraction

Brief summary

Diagnosing heart failure with preserved ejection fraction (HFpEF) in patients complaining exertional breathlessness can be challenging: diagnostic algorithms and scores have low sensitivity, and ageing-associated comorbidities can complicate the interpretation of symptoms. Thus, exercise right heart catheterization (RHC) or invasive cardiopulmonary exercise test (iCPET) have been advocated as gold-standard methods for HFpEF diagnosis. However, exercise RHC and iCPET are still not widely standardized methods, with results mainly coming from US cohorts (that may differ from Italian cohorts), and other provocative tests (e.g. non-invasive CPET, passive leg raising) may offer complementary diagnostic information.

Interventions

DIAGNOSTIC_TESTexercise test

exercise test

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

* dyspnea

Exclusion criteria

* known HFpEF

Design outcomes

Primary

Measure	Time frame	Description
Mortality	5 years	Incidence of mortality
Hospitalization for heart failure	5 years	Incidence of hospitalization for heart failure
Atrial fibrillation	5 years	Incidence of atrial fibrillation

Countries

Italy

Contacts

Primary ContactSergio Caravita, MD, PhD

s.caravita@auxologico.it+39 02 619112930

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026