Heart Failure With Preserved Ejection Fraction
Conditions
Brief summary
Patients with heart failure and a preserved left ventricular ejection fraction (HFpEF) almost invariably complain of exertional breathlessness. Abnormal cardiac hemodynamics with pulmonary congestion are believed to trigger dyspnea in this patients. However, some patients may complain of exertional breathlessness which seems to be out of proportion as compared with hemodynamic abnormalities. Chemoreflex sensitivity accounts for the ventilatory responses to a variety of chemical stimuli, including carbon dioxide produced by the organism during exercise. Chemoreflex sensitivity can be augmented in heart failure with reduced left ventricular ejection fraction, and an increased chemoreflex sensitivity has been linked to symptoms, neurohumoral activation, breathing disturbances, and adverse prognosis. However, the clinical correlates and implications of chemoreflex sensitivity in HFpEF have not been accurately studied. We aim to characterize chemoreflex sensitivity in patients with a diagnosis of HFpEF, and to correlate chemoreflex sensitivity with clinical and hemodynamic characteristics.
Interventions
DIAGNOSTIC_TESTchemoreflex evaluation
the ventilatory response to carbon dioxide and hypoxia will be assessed in study participants
Sponsors
Istituto Auxologico Italiano
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
Yes
Inclusion criteria
* diagnosis of symptomatic HFpEF (group 1) * diagnosis of asymptomatic left ventricular diastolic dysfunction with echocardiographic signs of PH (group 2) * healthy volunteers (group 3)
Exclusion criteria
* breastfeeding or childbearing
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| difference in chemoreflex sensitivity between HFpEF and healthy controls | 5 years |
Countries
Italy
Contacts
Primary ContactSergio Caravita, MD, PhD
Outcome results
None listed