Cohort Studies
Conditions
Keywords
Anxiety, Depression, Aged, Surgery, Volatile anaesthetics
Brief summary
This study is a retrospective analysis of a large-scale multicentre prospective cohort study that investigates the impact of volatile anaesthetics on the incidence of postoperative depression and anxiety among elderly patients.
Detailed description
Studies have suggested volatile anaesthetics may alleviate depression and anxiety in patients. However, there is a paucity of research in this area. The investigatorswanted to determine the association between volatile anaesthetics and depression/anxiety in elderly patients within 7 days after surgery. This study retrospectively analysed data from a prospective database of patients aged 65 and above who underwent non-cardiac, non-neurosurgical elective surgery in 18 tertiary hospitals across 10 provinces in China. Patients receiving volatile anaesthetics received at least one volatile anaesthetic (sevoflurane, isoflurane, desflurane), and those who received non-volatile anaesthetics did not receive any volatile anaesthetic. Binary logistic regression analyses were conducted, and propensity score-matching (PSM) and subgroup analyses were also applied.
Interventions
DRUGvolatile anaesthetic (sevoflurane, isoflurane, desflurane)
Patients receiving volatile anaesthetics received at least one volatile anaesthetic (sevoflurane, isoflurane, desflurane), and those who received non-volatile anaesthetics did not receive any volatile anaesthetic.
Sponsors
Beijing Tsinghua Changgeng Hospital
Peking University First Hospital
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Xiangya Hospital of Central South University
Beijing Anzhen Hospital
Central South University
Peking University People's Hospital
Zhejiang University
Fudan University
Sun Yat-sen University
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
China-Japan Friendship Hospital
The Affiliated Hospital Of Guizhou Medical University
First Affiliated Hospital of Xinjiang Medical University
First Affiliated Hospital of Guangxi Medical University
Taihe Hospital
Chinese PLA General Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Geriatric surgical patients ≥65 years old Non-selective cardiac surgery Non-neurosurgical
Exclusion criteria
1. underwent reoperation within 7 days 2. ASA classification of Ⅳ or above 3. history of serious mental illness or long-term use of psychotropic drugs 4. patients either died or were transferred to the intensive care unit within 7 days of the surgery 5. subjects with missing covariate data
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Depression | Depression within 7 days of surgery | Primary outcomes were depression Patient Health Questionnaire 9 (PHQ-9).The PHQ-9 is a nine-item questionnaire for screening on the presence of depressive symptoms and monitoring depression severity. Items were scored on a four-point scale with total scores ranging from zero to twenty-seven. Scores were defined as: ≥5 mild, ≥10 moderate, and ≥15 severe level of depression. The recommended screening cutoff was ≥10, corresponding with at least a moderate level of depression. The higher the score, the worse the situation. The total score ranges from 0 to 27, and higher scores indicate more depressive symptoms. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Anxiety | Anxiety within 7 days of surgery | The GAD-7 is a seven-item questionnaire for screening on the presence of generalized anxiety disorder and assessing its severity. Items were scored on a four-point scale with total scores ranging from zero to twenty-one. Scores were defined as: ≥5 mild, ≥10 moderate, and ≥15 severe anxiety. The recommended screening cutoff was ≥10, corresponding with at least a moderate level of anxiety. Higher scores mean more anxiety. |
Countries
China
Outcome results
None listed