European Registry of Transcatheter Repair for Tricuspid Regurgitation

Conditions

Heart Failure, Tricuspid Regurgitation, Valvular Heart Disease

Keywords

Tricuspid regurgitation, TEER, edge-to-edge repair

Brief summary

To investigate clinical and survival outcomes following transcatheter tricuspid valve repair or replacement.

Detailed description

Background and Rationale: Tricuspid regurgitation (TR) is a major health and economic burden due to high rates of heart failure hospitalizations, morbidity and mortality. Surcial treatment of TR is associated with high procedural and in-hospital mortality. Due to prohibitive surgical risk, a significant proportion of patients historically remained untreted beyond medical therapy. Transcatheter tricuspid valve (TV) repair and replacement techniques (TTVT) now offer a new treatment perspective for these patients. The EuroTR registry aims at optimizing patient selection prior to TTVT and thus treatment quality by collecting respective data in a real-world setting. Objectives: To investigate clinical and survival outcome following transcatheter tricuspid valve repair or replacement.

Gmeiner J, Stolz L, Kresoja KP, von Stein J, Fortmeier V, Pauschinger C, Rottbauer W, Kassar M, Goebel B, Denti P, Achouh P, Rassaf T, Barreiro-Perez M, Boekstegers P, Rück A, Zdanyte M, Adamo M, Vincent F, Schlegel P, Rosch S, Wild MG, Besler C, Toggweiler S, Brunner S, Grapsa J, Patterson T, Thiele H, Kister T, Tarantini G, Masiero G, De Carlo M, Sticchi A, Voss F, Polzin A, Popolo Rubbio A, Bedogni F, Stolte T, Nestelberger T, Benito-Gonzales T, Sánchez-Muñóz E, Konstandin MH, Van Belle E, Metra M, Geisler T, Estévez-Loureiro R, Mahabadi AA, Karam N, Maisano F, Lauten P, Praz F, Kessler M, Kalbacher D, Rudolph V, Iliadis C, Lurz P, Hausleiter J, EuroTR Investigators .

2026-05-20

10.1093/eschf/xvag103

Invasive Hemodynamics and Risk Stratification in T-TEER: Moving Beyond ESC Thresholds - EuroTR Registry Insights.

Masiero G, Arturi F, Ceni S, Panza A, Kresoja KP, von Stein J, Fortmeier V, Koell B, Rottbauer W, Kassar M, Goebel B, Denti P, Achouh P, Rassaf T, Barreiro-Perez M, Boekstegers P, Rück A, Zdanyte M, Adamo M, Vincent F, Schlegel P, Rosch S, Wild MG, Besler C, Toggweiler S, Brunner S, Grapsa J, Patterson T, Thiele H, Kister T, Sticchi A, De Carlo M, Voss F, Polzin A, Popolo Rubbio A, Bedogni F, Stolte T, Nestelberger T, Benito-González T, Sánchez-Muñóz E, Konstandin MH, Van Belle E, Metra M, Geisler T, Estévez-Loureiro R, Mahabadi AA, Karam N, Maisano F, Lauten P, Praz F, Kessler M, Kalbacher D, Rudolph V, Iliadis C, Lurz P, Hausleiter J, Stolz L, Tarantini G, EuroTR Investigators.

2025-11-14

10.1161/circinterventions.125.015964

Invasive Hemodynamics and Risk Stratification in T-TEER: Moving Beyond ESC Thresholds: EuroTR Registry Insights.

Masiero, Giulia, Arturi, Federico, Ceni, Sara, Panza, Andrea, Kresoja, Karl-Patrik et al. (58 authors)

Open Access CRIS of the University of Bern2025-11-14

10.48620/92825

Impact of age on outcomes after transcatheter tricuspid valve edge-to-edge repair: insights from EuroTR.

Novotny J, Stolz L, Kresoja KP, von Stein J, Fortmeier V, Pauschinger C, Rottbauer W, Kassar M, Goebel B, Denti P, Achouh P, Rassaf T, Barreiro-Perez M, Boekstegers P, Rück A, Zdanyte M, Adamo M, Doldi PM, Weckbach LT, Stocker TJ, Vincent F, Schlegel P, Rosch S, Wild MG, Besler C, Toggweiler S, Brunner S, Grapsa J, Patterson T, Thiele H, Kister T, Tarantini G, Masiero G, De Carlo M, Sticchi A, Voss F, Polzin A, Rubbio AP, Bedogni F, Konstandin MH, Van Belle E, Metra M, Geisler T, Estévez-Loureiro R, Mahabadi AA, Karam N, Maisano F, Lauten P, Praz F, Kessler M, Kalbacher D, Rudolph V, Iliadis C, Lurz P, Hausleiter J, EuroTR Investigators.

2025-09-23

10.1007/s00392-025-02702-8

Impact of Pulmonary Hypertension on Outcomes After Transcatheter Tricuspid Valve Edge-to-Edge Repair.

Stolz L, Kresoja KP, von Stein J, Fortmeier V, Koell B, Rottbauer W, Kassar M, Goebel B, Denti P, Achouh P, Rassaf T, Barreiro-Perez M, Boekstegers P, Rück A, Doldi PM, Novotny J, Zdanyte M, Adamo M, Vincent F, Schlegel P, von Bardeleben RS, Stocker TJ, Weckbach LT, Wild MG, Besler C, Brunner S, Toggweiler S, Grapsa J, Patterson T, Thiele H, Kister T, Tarantini G, Masiero G, De Carlo M, Sticchi A, Konstandin MH, Van Belle E, Metra M, Geisler T, Estévez-Loureiro R, Luedike P, Karam N, Maisano F, Lauten P, Praz F, Kessler M, Kalbacher D, Rudolph V, Iliadis C, Lurz P, Hausleiter J, EuroTR Investigators.

2024-10-287 citations

10.1016/j.jcin.2024.10.023

Interventions

DEVICET-TEER

T-TEER using the PACAL or TriClip device

Study design

Observational model

OTHER

Time perspective

OTHER

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

No

Inclusion criteria

* Patients treated with one of the following transcatheter devices for TV repair or replacement: PASCAL, TriClip, TricValve, Evoque, LuX-Valve * Age ≥ 18 years

Design outcomes

Primary

Measure	Time frame
All-cause mortality	5 years

Secondary

Measure	Time frame	Description
Procedural Safety	5 years	periprocedural and in-hospital adverse events
Heart Failure Biomarker	5 years	NT-proBNP level
Dyspnea on exertion	5 years	New York Heart Association (NYHA) functional class
Functional capacity	5 years	6-minute walk distance (6MWD)
Right ventricular size	5 years	Mid-ventricular diameter of the right ventricle measured by echocardiography
Technical success	5 years	absence of procedural mortality, successful access, delivery and retrieval of the delivery system, successful deployment and positioning, freedom from emergency surgery
Tricuspid regurgitation reduction	5 years	Tricuspid regurgitation severity measured by echocardiography
Tricuspid valve stenosis	5 years	Transvalvular pressure gradient measured by echocardiography
Pulmonary hypertension	5 years	Pulmonary artery pressure measured by echocardiography
Right heart congestion	5 years	Inferior vena cava dimensions measured by echocardiography
Hospitalization for heart failure	5 years	Date and number of heart failure hospitalizations after the index procedure
Right ventricular function	5 years	Right ventricular fractional area change measured by echocardiography

Countries

Germany

Contacts

Primary ContactJörg Hausleiter, Prof. Dr.

Joerg.Hausleiter@med.uni-muenchen.de+49 89 4400 72360

Backup ContactLukas Stolz, Dr.

Lukas.Stolz@med.uni-muenchen.de

Outcome results

None listed