Influence of Intraoperative Blood Salvage and Autotransfusion on Tumor Recurrence After Deceased Donor Liver Transplantation

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06307158

Enrollment

998

Registered

2024-03-12

Start date

2015-01-01

Completion date

2021-12-31

Last updated

2024-03-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Liver Transplant; Complications

Brief summary

The practice of intraoperative blood salvage and autotransfusion (IBSA) during deceased donor liver transplantation (DDLT) for hepatocellular carcinoma (HCC) can potentially reduce the need for allogeneic blood transfusion. However, implementing IBSA remains debatable due to concerns about its possible detrimental effects on oncologic recurrence. Hence, a nationwide multi-center study was conducted to investigate further the association between IBSA and post-transplant HCC recurrence, including a stratified subgroup analysis.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

* adult-to-adult deceased donor liver transplantation for hepatocellular carcinoma

Exclusion criteria

* patients under 18 years of age * presence of extrahepatic metastasis * combined kidney transplantation * reduced-size or split liver transplantation * re-transplantation

Design outcomes

Primary

Measure	Time frame	Description
Postoperative recurrence of liver cancer	2015.1.1-2020.12.31	The overall incidence of HCC recurrence (intrahepatic or extrahepatic) after LT.

Outcome results