Idiopathic Inflammatory Myopathies
Conditions
Brief summary
Idiopathic inflammatory myositis (IIM), also known as myositis, are a heterogeneous group of diseases characterized by chronic inflammation of striated muscles and skin, with different clinical manifestations, treatment responses, and prognosis. This project will build a clinical follow-up cohort for idiopathic inflammatory myositis (IIM) centered on Renji Hospital, Shanghai Jiao Tong University School of Medicine, to promote the clinical and pathogenesis of this group of diseases.
Interventions
OTHERno interventions were involved
no interventions were involved
Sponsors
RenJi Hospital
Study design
Observational model
COHORT
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
Subjects must meet the following criteria for inclusion in this study: meet the 2017 EULAR/ACR classification criteria for inflammatory myopathy (IIM) or the 2018 ENMC-DM classification criteria (see above), plus: 1. Age≥ 18 years old and ≤ 75 years old 2. Meet the 2017 EULAR/ACR classification criteria for inflammatory myopathy (IIM), the above score ≥ 5.5 points if there is no muscle biopsy, and 6.7 points ≥ if there is muscle biopsy 3. Cooperate with follow-up, examination and treatment and voluntarily sign the informed consent form. \-
Exclusion criteria
Potential subjects who meet the inclusion criteria will be excluded if they meet any of the following criteria: a. IIM with other connective tissue diseases; b. Negative myositis antibody test; c. Those who are in the period of acute infection, or have a history of active tuberculosis in the past; d. People with allergies or allergies to multiple drugs; e. Those who have mental illness or other reasons and cannot cooperate with examination, follow-up or treatment; f. Women who are pregnant, or are trying to become pregnant; g. Those who are participating in or have participated in clinical trials within the specified time. \-
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| High Resolution Computed Tomography of Chest | three months | High Resolution Computed Tomography of Chest will be used to assess the incidence of interstitial pneumonia. |
| Cutaneous Disease Area and Severity Index | three months | Cutaneous Disease Area and Severity Index will be used to assess the the severity of the rash. |
| Forced vital capacity | three months | t refers to the maximum amount of air that cr trying to inhale as quickly as possible. |
| Manual Muscle Testing | three months | Manual Muscle Testing will be used to assess patients with muscle weakness. |
| Forced expiratory volume in one second | three months | It refers to the volume of the maximum exhalation exhaled in the first second of the maximum deep inhalation. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Serum creatine kinase | three months | Serum creatine kinase will be used to assess the disease activity in idiopathic inflammatory myopathies. |
Outcome results
None listed