Thulium Fiber Laser vs. Holmium:YAG Laser for the Ureteroscopic Treatment of Patients With Urinary Stone Disease

Comparing the Efficacy of Thulium Fiber Laser vs. Holmium:YAG Laser for the Ureteroscopic Treatment of Patients With Urinary Stone Disease: a Randomized Controlled Trial

Status

Recruiting

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT06306222

Enrollment

120

Registered

2024-03-12

Start date

2023-11-23

Completion date

2026-02-23

Last updated

2024-03-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Kidney Stone, Ureteral Stone

Brief summary

This is a randomized controlled trial which aims to compare the efficacy and safety of Thulium fiber laser (TFL) and holmium:yttrium-aluminum-garnet (Ho:YAG) laser ablation during the treatment of upper urinary tract stone disease with flexible ureteroscopy, demonstrating clinical superiority of TFL.

Interventions

DEVICELaser lithotripsy

Ureteroscopic laser lithotripsy

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

18 Years to 99 Years

Healthy volunteers

Inclusion criteria

* Renal/ureteral stones \> 4 mm

Exclusion criteria

* Anatomical abnormalities

Design outcomes

Primary

Measure	Time frame
Lithotripsy speed	Through study completion, an average of 1 year

Secondary

Measure	Time frame
Stone free rate	3 months after the procedure

Countries

Italy

Contacts

Primary ContactD'Arma Alessia

darma.alessia@hsr.it+390226435506

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026