Bone Loss, Osteoporosis, Osteopenia
Conditions
Brief summary
Bone mineral density is an important measurement to detect osteoporosis. The goal of this clinical trial is to compare bone mineral density measurements in CT examinations and DXA scans. The main question it aims to answer is: * How good is the measurement of bone mineral density in the new photon-counting CT in comparison to DXA * How can we optimize the CT scan for bone mineral density Participants will undergo: * Clinically indicated CT scan on day of inclusion * Study related DXA scan on a separate appointment
Interventions
DIAGNOSTIC_TESTBone Mineral Density quantification
In the first visit, participants receive clinically indicated CT scan, where bone mineral density will be derived. In a second, study related visit, participants will receive a DXA scan for bone mineral quantifications.
Sponsors
Hatem Alkadhi
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Informed Consent signed by the subject * Referral to a regular clinically indicated CT examination covering the lumbar area (e.g., Abdomen, Thorax + Abdomen, Neck + Thorax +Abdomen) * Informed written and oral consent (interpreter present in case of foreign language patients) * No contraindication to the clinically indicated CT examination
Exclusion criteria
* Patients \< 18 years * Pregnant women * Vulnerable subjects * Contraindications to the clinically indicated CT scan * Multiple Myeloma * Diffuse bone metastasis * Fixateur interne in the lumbar spine * Kyphoplasty in the lumbar spine * Enterally administrated contrast agent * Obtaining informed consent is not possible * Withdrawal of consent orally or in writing * Inability to follow the procedures of the investigation, e.g., due to language problems, psychological disorders, dementia, etc. of the subject * Immobility (patients confined to a wheelchair or to bed)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Bone mineral density CT | Immediately after CT scan of the participant. | Bone mineral density derived from CT Scan |
| Bone mineral density Dual-energy x-ray absorptiometry (DXA) | Immediately after DXA scan of the participant. | Bone mineral density derived from DXA Scan |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Correlation between height and bone mineral density | 1 year | Correlation analysis by means of linear regression and pearson correlation between height (in cm) and bone mineral density |
| Correlation between age and bone mineral density | 1 year | Correlation analysis by means of linear regression and pearson correlation between age (in years) and bone mineral density |
| Correlation between body mass index (BMI) and bone mineral density | 1 year | Correlation analysis by means of linear regression and pearson correlation between body mass index (BMI, in kg/m\^2) and bone mineral density |
| Correlation between weight and bone mineral density | 1 year | Correlation analysis by means of linear regression and pearson correlation between weight and bone mineral density |
| Correlation between sex and bone mineral density | 1 year | Correlation analysis by means of linear regression and pearson correlation between sex (male/female) and bone mineral density |
Countries
Switzerland
Outcome results
None listed