Elevated Lipoprotein(a) in Hospital Staff

Investigating The Prevalence and Clinical Significance of Elevated Lipoprotein(a) Blood Levels in Hospital Staff

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06304415

Acronym

LPACO

Enrollment

2800

Registered

2024-03-12

Start date

2024-04-01

Completion date

2036-12-31

Last updated

2026-03-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiovascular Diseases, Hypercholesterolemia, Lipoprotein Types--Lp System Lp(A) Hyperlipoproteinemia

Brief summary

The objective of this study is to investigate the prevalence of elevated Lp(a) in the working general population.

Detailed description

The objective of this study is to investigate the prevalence of elevated lipoprotein(a) concentrations and distribution of lipoprotein(a) in a working general population. This is a prospective study investigating the association of lipoprotein(a) with cardiovascular markers and outcomes.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

21 Years to 100 Years

Healthy volunteers

Yes

Inclusion criteria

1. Any healthcare workers working in healthcare settings (regardless of PHI and/or private setting) aged 21 and above OR family member such as father, mother, siblings, grandparents, spouse and children aged 12 and above of recruited staff with high Lpa ≥120nmol/l 2. Study team members can also be recruited because we are trying to find the prevalence of elevated Lp(a)

Exclusion criteria

1. Inability to provide informed consent. 2. Pregnant women. 3. Prisoner

Design outcomes

Primary

Measure	Time frame	Description
Distribution and prevalence of elevated Lipoprotein(a)	3 years	Investigate the distribution lipoprotein(a) and prevalence of elevated lipoprotein(a) concentrations in various ethnicities.

Secondary

Measure	Time frame	Description
Correlation of lipoprotein(a) with cardiovascular outcomes	10 years	Observational study to assess the correlation of degree of elevation of lipoprotein(a) with cardiovascular outcomes prospectively.
Genetic variants of lipoprotein(a) and cardiovascular outcomes atherosclerotic events	10 years	Assess the association of genetic variants of lipoprotein(a) with the measured lipoprotein(a) concentrations in various ethnicities, and prospectively assess the association of these genetic variants with cardiovascular outcomes

Countries

Singapore

Contacts

PRINCIPAL_INVESTIGATORLoh Wann Jia

Singhealth Foundation

Outcome results