Hypertension
Conditions
Brief summary
Inorganic nitrite and nitrate can be reduced to NO and NO-related species such as S-nitrosothiols via the nitrate-nitrite-NO pathway. This is due to the reduction of nitrate to nitrite by the action of bacteria in the mouth and the reduction of nitrite to NO depending on the acidic pH on the stomach or by enzymes with nitrite-reductase activity. The acidic environment of the stomach is very important to the formation of NO and S-nitrosothiols and several studies suggest that changes in gastric pH can affect this conversion. In this context, bariatric surgery, by altering the anatomy of the stomach and increasing gastric pH, can affect the nitrate-nitrite-NO pathway and change the antihypertensive and antioxidant effect of sodium nitrate.
Interventions
DIETARY_SUPPLEMENTSodium nitrate
Sodium Nitrate
Sponsors
University of Sao Paulo
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* For volunteers who underwent bariatric surgery: 1. Female; 2. Age over 18 years old and under 60 years old; 3. Having had bariatric surgery more than 1 and a half years ago; 4. Present stabilized weight loss; * For voluntary controls: 1. Female; 2. Age over 18 years old and under 60 years old;
Exclusion criteria
* For volunteers who underwent bariatric surgery and controls: 1. Having uncontrolled blood pressure (above 160/100 mmHg), even with use regulate up to two antihypertensive agents; 2. Hypertensive patients must be using a maximum of two antihypertensives; 3. Have Diabetes Mellitus or other endocrinopathy; 4. Have kidney or liver failure; 5. Individuals who smoke.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Assess changes in s-nitrosothiols | 14 days | Change in s-nitrosothiols concentration in plasma After Sodium Nitrate Treatment |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Assess changes in blood pressure | 14 days | Change in Blood Pressure After Sodium Nitrate Treatment by Ambulatory blood pressure monitors (ABPMs) |
| Assess changes in endotelial function | 14 days | Change in endotelial function After Sodium Nitrate Treatment by Endopat |
| Assess changes in Vascular stiffness | 14 days | Change in Vascular stiffness After Sodium Nitrate Treatment by pulse wave velocity (PWV) |
| Assess changes in nitrate concentration | 14 days | Change in nitrate concentration in plasma After Sodium Nitrate Treatment |
| Assess changes in nitrite concentration | 14 days | Change in nitrite concentration in plasma After Sodium Nitrate Treatment |
Countries
Brazil
Outcome results
None listed