Knee Arthritis, Knee Arthropathy, Knee Disease, Knee Osteoarthritis, Knee Pain Chronic, Knee Rheumatism
Conditions
Brief summary
Effect of iPACK block with Adductor Canal Block and ESPB on pain management, and NLR and PLR following knee arthroplasty
Detailed description
Knee arthroplasty is one of the most common orthopaedic procedures, especially in elderly patients, due to the deformation of joints. Patients may complain of severe pain due to surgical trauma and prostheses. Regional anaesthesia methods may be performed to reduce the surgery's induced stress response, opioid consumption, and opioid-related side effects. In recent years, the influence of regional anesthesiology on reducing the inflammatory response after surgical procedures has been emphasised. However, very few studies have evaluated the effect of various methods of anaesthesia on the NLR and PLR. This is the first study to investigate the effect of regional anaesthesia on the pain managementonse expres and stress respsed by the NLR and PLR in patients undergoing knee replacement surgery.
Interventions
DRUGRopivacaine 0.2% Injectable Solution
iPACK block + Adductor Canal Block
DRUGcontrol group
only spinal anesthesia
Sponsors
Poznan University of Medical Sciences
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Caregiver, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 100 Years
Healthy volunteers
No
Inclusion criteria
* Patients with ASA classification I-III, Aged 20-90 years, Who will be scheduled for knee arthroplasty under spinal anaesthesia.
Exclusion criteria
* patients who have a history of bleeding diathesis, * take anticoagulant therapy, * have a History of chronic pain before surgery, * have Multiple trauma, cannot assess their pain (dementia), * have been operated on under general anaesthesia, * have an infection in the area and do not accept the procedure
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Opioid consumption | 48 hours after surgery | Total opiate consumption after surgery |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Time to first rescue opiate analgesia | 48 hours after procedure | Time after surgery when the patient needs opiate for the first time |
| Numerical Rating Scale [range 0:10] | Time Frame: 4 hours after surgery | Postoperative pain assessment will be performed using the NRS score (0 = no pain, 10 = the most severe pain felt) |
| Neutrophil-to-lymphocyte ratio | 24 hours after surgery | Neutrophil-to-lymphocyte ratio |
| Platelet-to-lymphocyte ratio | 24 hours after surgery | Platelet-to-lymphocyte ratio |
| Quadriceps muscle strength assessed using medical research council scale [range 0:5] | Postoperative 24 hours period | Quadriceps muscle strength (knee extension and hip adduction) will be evaluated according to the medical research council muscle strength rating |
Countries
Poland
Contacts
Primary ContactMalgorzata Domagalska, Ph.D.
Backup ContactMałgorzata Domagalska, Ph.D.
Outcome results
None listed