Anxiety, Depression
Conditions
Brief summary
Objective: To collect preliminary data and assess the preliminary effectiveness of a game-based digital therapeutics (DTx) intervention for individuals with symptoms of anxiety and depression, and to investigate whether reinforcement learning (RL) can personalize the intervention and enhance effectiveness. Design: Randomized controlled trial with three arms. Setting: Internet-based recruitment and delivery of the intervention. Participants: 223 individuals with symptoms of anxiety and depression, aged between 18 and 50 years. Interventions: Participants were randomly assigned to one of three groups: game-based DTx with RL algorithm (RL algorithm group), game-based DTx without RL algorithm (no algorithm group), and a blank control group. Main Outcomes and Measures: The primary outcomes were reductions in symptoms of anxiety and depression, measured using the Patient Health Questionnaire-9 and Generalized Anxiety Disorder 7-item scales. Response rates and rates of recovery, as well as the impact of demographic variables, were also examined.
Interventions
BEHAVIORALReinforcement learning algorithm powered cognitive and behavioral intervention
Reinforcement learning algorithm powered cognitive and behavioral intervention
BEHAVIORALcognitive and behavioral intervention
cognitive and behavioral intervention
Sponsors
Adai Technology (Beijing) Co., Ltd.
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
1. age between 18 and 60 years; 2. having a PHQ-9 score or a GAD-7 score upon enrollment; 3. being able to operate a smartphone fluently; 4. having normal vision after correction
Exclusion criteria
1. clinical diagnoses of severe psychiatric conditions such as schizophrenia or bipolar disorder; 2. at high risk of suicide or self-harm; 3. having significant cognitive impairments; 4. active substance abuse or dependence; 5. currently undergoing other psychological or pharmacological treatments for depression or anxiety; 6. pregnant individuals or those with postpartum depression, and those with serious physical health conditions that could impact mental health.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| PHQ9 Response | Immeidately after intervention | A user is said to responded to the intervention if the PHQ9 score dropped no less than 50% compared to the baseline |
| GAD7 Response | Immeidately after intervention | A user is said to responded to the intervention if the PHQ9 score dropped no less than 50% compared to the baseline |
Countries
China
Outcome results
None listed