Dermatologic Disease
Conditions
Brief summary
Scars and keloids cause patients severe morbidity and psychological distress. Hypertrophic scars rise above the skin but stay within the scar boundaries, while keloids expand. The development of keloids and hypertrophic scars is a consequence of insufficient wound healing. These lesions are distinguished by excessive ECM deposition. Excessive ECM deposition is caused by increased inflammatory and proliferative processes and decreased remodeling activities. These scarring lesions are also linked to genetic and systemic causes
Interventions
DRUGCholecalciferol
Vitamin D has various critical regulatory roles, including inflammatory control, cellular proliferation and differentiation, and wound healing regulation.
Sponsors
Mostafa Bahaa
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 50 Years
Healthy volunteers
No
Inclusion criteria
\- Age from 12 years to 50 years. Patients with hypertrophic scars and keloids
Exclusion criteria
Age below 12 years and above 50 years. Patients received other treatment modalities for hypertrophic scars and keloids. Systemic and other skin diseases. Patients were already receiving supplemental vitamin D.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Clinical scoring by Vancouver Scale Score | 3 months | Four characteristics of the scar are assessed. These are: vascularity, height, pliability, and pigmentation. Each characteristic is given a score, which are added together to give an overall score between 0 and 13 |
Countries
Egypt
Outcome results
None listed