Comparison Between Drugs for Control of Emetic Attacks During Caesarean Delivery

Comparison Between Propofol, Ondansetron and Pregabalin for Control of Emetic Attacks During Caesarean Delivery With Spinal Anesthesia: Randomized Clinical Trial

Status

Not yet recruiting

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT06300346

Enrollment

Registered

2024-03-08

Start date

2024-03-01

Completion date

2024-08-18

Last updated

2024-03-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Emetic Attacks During Caesarean Delivery With Spinal Anesthesia

Brief summary

Single shot spinal anesthesia is widely used for most surgical operations especially in obstetric such as hysterectomy, tubal ligation after vaginal delivery, cesarean and curettage etc.; however, in general, cesarean is considered as the most common indication for spinal anesthesia in pregnant women Intra-operative nausea and vomiting/retching (NVR) may be experienced by 20% to 80% of women undergoing cesarean section (CS) with subarachnoid anesthesia (SA) in the absence of antiemetic prophylaxis. Different treatment options are available to reduce post operative nausea and vomiting (PONV) so we will make a Comparison between Propofol, Ondansetron and Pregabalin for Control of Emetic Attacks during Caesarean Delivery with Spinal Anesthesia

Interventions

DRUGPropofol

Ondansetron

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

NONE

Eligibility

Sex/Gender

FEMALE

Age

21 Years to 40 Years

Healthy volunteers

Yes

Inclusion criteria

* Age: 21-40 years old. * Physical status American Society of Anesthesiologists (ASA)I&II. * Body mass index (BMI) \< 35&\>20 kg/m2. * Elective uncomplicated cesarean section under spinal anesthesia.

Exclusion criteria

* Patient refusal. * Patients with known history of allergy to study drugs. * Advanced hepatic, renal and respiratory diseases. * Psychological and mental disorders. * Patient with reduced level of consciousness. * Hypertensive, cardiac, and diabetic patients. * Patients receiving anticoagulants therapy or suspected coagulopathy.

Design outcomes

Primary

Measure	Time frame	Description
Incidence of nausea and vomiting with spinal anesthesia	5 months	To compare between Propofol, Ondansetron and Pregabalin for control of emetic attacks during caesarean delivery with spinal anesthesia.

Secondary

Measure	Time frame	Description
Measurement of hemodynamics postoperative	5 months	Measurement of hemodynamics postoperative and Incidence of other side effects as :hypotension measured by non invasive blood pressure monitoring

Contacts

Primary ContactEbtihal A Abd-Ellateef, resident

ebtehalahmed@med.sohag.edu.eg01119925603

Backup ContactAhmed M Abd-Elmaboud, assistant professor

01150217744

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026