Cetylated Fatty Acid for Reducing Pain After TKA

Efficacy of Cetylated Fatty Acid for Alleviating Postoperative Pain After Total Knee Arthroplasty: A Randomized Placebo-controlled Trial

Status

Recruiting

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT06300008

Enrollment

Registered

2024-03-08

Start date

2024-02-12

Completion date

2024-12-31

Last updated

2024-03-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative Inflammation, Postoperative Pain

Keywords

Cetylated fatty acid, TKA, Postoperative pain, Inflammation

Brief summary

To compare efficacy of cetylated fatty acid with placebo for reducing postoperative pain after unilateral TKA. The hypothesis is topical cetylated fatty acid can mitigate postoperative pain after TKA.

Interventions

DRUGcetylated fatty acid

use approximately 3 cm long of cream per each side of knee, then apply on the operated knee until completely absorb

DRUGPlacebo

use approximately 3 cm long of cream per each side of knee, then apply on the operated knee until completely absorb

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

50 Years to 80 Years

Healthy volunteers

Inclusion criteria

* Age 50-80 years * Osteoarthritic knee patients underwent unilateral primary TKA * Participants understand and consent to the protocol of the trial

Exclusion criteria

* Inflammatory knee arthritis * Previous knee surgery or trauma * Previous knee infection * Skin problem around the knee such as eczema, psoriasis, wound infection * Allergy to studied drug

Design outcomes

Primary

Measure	Time frame	Description
Visual analog scale	post-op Day2	VAS (0-100) at rest and on motion
inflammatory marker	post-op day2	ESR and CRP
Knee skin temperature	post-op Day2	evaluated by digital infrared thermometer at 4 different locations on the anterior aspect of the knee independently (superomedial, superolateral, inferomedial, inferolateral borders of the patella) compared with the contralateral knee

Secondary

Measure	Time frame	Description
Knee circumference (cm)	post-op Day2	Measured by tape at midpoint of patella
Thai forgotten joint score	post-op week2	—
Knee Range of Motion	post-op Day2	Flexion and extension angle
Modified WOMAC	post-op week2	Total & Subscore

Countries

Thailand

Contacts

Primary ContactSupakit Kanitnate, M.D.

naypeng@hotmail.com66899853635

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026