Prognostic, Pyelonephritis
Conditions
Keywords
acute kidney injury, renal remplacement therapy, hemodialysis, acute respiratory distress, hemodynamic failure
Brief summary
Acute obstructive pyelonephritis is a condition with a high risk of complications and may require admission to the intensive care unit. Most of the available data on this condition comes from small, retrospective, single-centre series. To date, no large-scale study has examined the factors associated with the prognosis of patients admitted to intensive care for acute obstructive pyelonephritis. The aim of this study is to describe the population and prognosis of patients admitted to the intensive care unit for the management of acute obstructive pyelonephritis, and to identify factors associated with a poor prognosis in these patients.
Detailed description
The retrospective and multicenter study consists of a retrospective and pseudonymous collection of data from medical reports of patients treated, over the period 2015-2022, in each intensive care unit agreeing to participate, . Investigators from each participating center will be responsible for screening on all hospitalized patients over the period 2015-2022. Patients who have been hospitalized for the management of acute obstructive pyelonephritis will be included, in the absence of non-inclusion criteria.
Interventions
None listed
Sponsors
Assistance Publique - Hôpitaux de Paris
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 100 Years
Healthy volunteers
No
Inclusion criteria
* Patients over 18 years of age * Hospitalized in intensive care for management of acute obstructive pyelonephritis * Patients affiliated to a Social Security System
Exclusion criteria
* Pregnancy * Opposition to data use * Persons under legal protection (curatorship, guardianship), legal safeguards
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary endpoint will be a combined endpoint of death, and/or stage 3 AKI ( KDIGO classification), and/or non-recovery of renal function. | up to 30 days after admission to intensive care |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Death | up to 30 days after admission to intensive care | — |
| Stage 3 Acute kidney injury (KDIGO classification) | up to 30 days after admission to intensive care | — |
| failure to recover renal function | up to 30 days after admission to intensive care . | defined as creatinine levels greater than 150% of baseline value |
| the incidence of acute renal failure defined by KDIGO 1 | up to 30 days after admission to intensive care | — |
| the incidence of acute renal failure defined by KDIGO 2 and 3 | up to 30 days after admission to intensive care | — |
| the incidence of Renal replacement therapy | up to 30 days after admission to intensive care | — |
| the incidence of non-recovery of renal fuction | up to 30 days after admission to intensive care | — |
| The number of days alive without Renal replacement therapy | up to 30 days after admission to intensive care | — |
| The number of days alive without catecholamines | up to 30 days after admission to intensive care | — |
| The number of days alive without antibiotics | up to 30 days after admission to intensive care | — |
| The number of days alive without | up to 30 days after admission to intensive care | — |
| Death rate | up to 30 days after admission to intensive care | — |
Countries
France
Contacts
PRINCIPAL_INVESTIGATORMaxime Dr COUTROT, MD
Hopital saint Louis-APHP
Outcome results
None listed