Solid Tumors
Conditions
Brief summary
The research project focuses on analyzing the spatial organization of cells within various solid tumors, utilizing advanced technologies enabling in-depth multi-parametric analysis of tumor and immune cells. The primary objective is to understand the spatial distribution of cellular subpopulations within each type of tumor, while secondary objectives include correlating these data with clinical aspects and identifying potential therapeutic targets. The study involves 1000 patients with primary or metastatic tumors and spans a duration of 5 years, from 2024 to 2028. No experimental treatments are planned; rather, only spatial imaging analyses with multiple markers will be conducted. Data analysis involves descriptive statistical methods and hypothesis testing to generate hypotheses for subsequent studies. The analyses will be performed using SPSS® version 21.0 software for Windows®.
Interventions
OTHERSpatial analysis of paraffin samples from solid tumors
The intervention involves the collection of tumour samples included in paraffin present in the pathological anatomy archive or requested to external archives for samples older than 2003 and the subsequent multiparametric spatial analysis of the main populations of the microenvironment tumor.
Sponsors
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* male or female subjects aged 18 years * primary or metastatic tumors Diagnosed by histology and/or radiological evidence, RNM, or endoscopic * signature of informed consent * substitute declaration to the consent form where applicable
Exclusion criteria
* previous unrelated tumour disease * significant acute or chronic infections (HIV, HCV and HBV infections) and/or ongoing bacterial and viral infections * active autoimmune disease * pregnant or breastfeeding * patients who do not sign informed consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Spatial analysis of cancer cells | 7 days | Spatial distribution analysis of the main cell subpopulations characterising the tumours studied. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Comparison of clinical data | 1 day | Correlation of spatial analysis data with patient clinical data |
| Identification of therapeutic targets | 4 weeks | Identification of possible therapeutic targets of different subpopulations |
Countries
Italy
Contacts
Primary ContactAlessandro Sgambato
Outcome results
None listed