Autonomic and Metabolic Response to Cardiac Rehabilitation After Acute MI

Autonomic and Metabolic Response to Cardiac Rehabilitation After Acute Myocardial Infarction

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06298513

Acronym

RIABILITOMICA

Enrollment

Registered

2024-03-07

Start date

2023-05-02

Completion date

2025-01-13

Last updated

2025-08-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Myocardial Infarction: Rehabilitation Phase

Keywords

myocardial infarction, cardiac rehabilitation, metabolomic, autonomic nervous ststem

Brief summary

Ischemic heart disease remains the leading cause of death in the western world. The beneficial effects of cardiac rehabilitation on the evolution of ischemic heart disease are known, but the effects of rehabilitation on the metabolic processes of the patients are so far poorly understood. Metabolomics is the qualitative/quantitative analysis of the body's metabolic responses to pathophysiological stimuli or genetic alterations. Metabolic changes caused by physical activity have been demonstrated in obese and diabetic patients and in athletes. Aim of the study is to evaluate whether cardiac rehabilitation after a first myocardial infarction induces changes in the metabolic state of patients, and whether these changes may be related with changes in the usual risk factors (i.e. glyco-lipidic profile, natriuretic peptides, homocysteine).

Interventions

OTHERCardiac rehabilitation

Six weeks of cardiac rehabilitation with physical training

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

MALE

Age

25 Years to 75 Years

Healthy volunteers

Inclusion criteria

* recent first acute myocardial infarction

Exclusion criteria

* severe diabetes

Design outcomes

Primary

Measure	Time frame	Description
Changes in purine after rehabilitation	Baseline and after 6 weeks of rehabilitation	The concentration of purine will be calculated after rehabilitation, and compared to its baseline concentration by a paired T test analysis.
Changes in histidine after rehabilitation	Baseline and after 6 weeks of rehabilitation	The concentration of purine will be calculated after rehabilitation, and compared to its baseline concentration by a paired T test analysis
Changes in galactose after rehabilitation	Baseline and after 6 weeks of rehabilitation	The concentration of galactose will be calculated after rehabilitation, and compared to its baseline concentration by a paired T test analysis.

Countries

Italy

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026