Neuropathic Pain
Conditions
Keywords
Lidocaine, Ketamine, Pain measurement, scale
Brief summary
This study aimed to evaluate and compare the efficacy of ketamine and lidocaine infusion in patients with chronic peripheral neuropathic pain. Patients who received intravenous ketamine infusion and the other patient group who received intravenous lidocaine infusion were evaluated in the study. Pain scores and quality of life were assessed with scales before treatment at two weeks, two months, and six months after treatment.
Detailed description
This study, it was aimed to evaluate and compare the efficacy of intravenous infusion of ketamine and lidocaine, which have been known and used in pain management and which have recently increased interest in the treatment of peripheric neuropathic pain.
Interventions
DRUGKetamine
Ketamine infusion was administered at 1 mg/kg (in 1 hour)
DRUGLidocain
Lidocaine infusion was administered at 3 mg/kg (in 1 hour)
Sponsors
Hacettepe University
Study design
Observational model
CASE_CROSSOVER
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Inclusion criteria
* 18-65 years of age * Patients with peripheral neuropathic pain (radicular neuropathy, diabetic neuropathy, complex regional pain syndrome type 2, traumatic peripheral nerve injury, trigeminal neuralgia, postherpetic neuralgia) * Patients who was evaluated by DN4 scores with of ≥4 points
Exclusion criteria
* Patients with central nervous system disease . * Patients with cancer related neuropatic pain. * Patients with central neuropathic pain patterns. * Patients with renal, hepatic, cardiovascular, and psychiatric diseases. * Patients whose treatment could not be completed due to side effects or other reasons. * Patients who had lost their follow-up .
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Neuropathic Pain Scale | Before treatment at two weeks, two months, and six months after treatment.The 7 symptoms items are scored by interviewing the patient.The scores are added and a score of 4 or more outout of ,10 point (severe pain ) is suggestive of neuropathic pain. | Neuropathic Pain 4 Questions (DN4) |
| Pain Rating Scale | Before treatment at two weeks, two months, and six months after treatment.NRS in which individuals rate their pain on an ten-point numerical scale. Zero:''no pain at all' ten-point ''severe pain'' | Numeric Rating Scale |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Quality of Life Scale | Before treatment at two weeks, two months, and six months after treatment.12-question survey PCS and the MCS Scores above 50 indicate a better-than-average health-related quality of life, while scores below 50 suggest below-average health. | Short form-12 (SF-12) |
Countries
Turkey (Türkiye)
Outcome results
None listed